Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), effectively targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s, belonging to the disulfide-rich, Ca2+-dependent enzyme family, catalyze the hydrolysis of glycero-phospholipids at the sn-2 position, resulting in the release of a fatty acid and a lysophospholipid. ROC-0929 holds promise in researching inflammation-related diseases.
Pack Size | Availability | Price/USD | Quantity |
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10 mg | Inquiry | $ 995.00 |
Description | ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), effectively targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s, belonging to the disulfide-rich, Ca2+-dependent enzyme family, catalyze the hydrolysis of glycero-phospholipids at the sn-2 position, resulting in the release of a fatty acid and a lysophospholipid. ROC-0929 holds promise in researching inflammation-related diseases. |
Targets&IC50 | GX (human):80 nM |
Molecular Weight | 561.65 |
Formula | C30H31N3O6S |
CAS No. | 1048660-43-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ROC-0929 1048660-43-0 ROC 0929 ROC0929 inhibitor inhibit