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TV 3279

Catalog No. T77332 CAS 209394-29-6

TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.

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TV 3279, CAS 209394-29-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 440.00
10 mg	In stock	$ 648.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 1,870.00
500 mg	In stock	$ 3,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 411.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.
In vivo	Chronic TV3279 (26 mg kg-1 for 21 days; rats) similarly inhibited ∼50% of striatal ChE activity but did not affect MAO activity or amine levels. Accordingly, chronic TV3279 abolished the ability of TCP to initiate L-dopa-induced hyperactivity. In contrast, chronic as well as acute treatments with TV3279 reduced spontaneous motor activity.[2]

Molecular Weight	272.34
Formula	C16H20N2O2
CAS No.	209394-29-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.73 mg/mL (10.01 mM)

References and Literature

1. Sterling J, et al. Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem. 2002;45(24):5260-5279. 2. Sagi Y, et al. The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L-dopa and L-tryptophan, in rats. Br J Pharmacol. 2005;146(4):553-560. 3. Weinstock M, et al. Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression. Psychopharmacology (Berl). 2002;160(3):318-324.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library TGF-beta/Smad Compound Library Bioactive Compounds Library Max Bioactive Compound Library Kinase Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TV 3279 209394-29-6 Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling BCL PKC TV3279 TV-3279 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.