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2-MPPA

Name: 2-MPPA
Brand: TargetMol
SKU: T22497
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22497Cas No. 254737-29-6

Alias GPI-5693, GPI5693, 2MPPA

2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.

2-MPPA

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Purity: 99.81%

Catalog No. T22497Alias GPI-5693, GPI5693, 2MPPACas No. 254737-29-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$689	In Stock	In Stock
100 mg	$1,230	-	In Stock
200 mg	$1,670	-	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.
Targets&IC50	GCP II:90 nM
In vitro	The application of 2-MPPA (1-20 μM) had no effect on the intrinsic membrane properties of CA3 pyramidal neurons recorded in vitro in whole-cell current clamp or voltage clamp mode. [3]
In vivo	2-MPPA (30 mg/kg intraperitoneally administered) increased jumping behavior in morphine-dependent mice. Opioid-dependent mice treated with 2-MPPA (30 mg/kg, intraperitoneal injection) showed a large number of episodes of tooth trembling. [1] 2-MPPA (10, 30, or 100mg/kg orally) significantly alleviated dizoxepine (0.1mg/kg) -induced PPI deficits in mice in a dose-dependent manner. [2]
Synonyms	GPI-5693, GPI5693, 2MPPA

Chemical Properties

Molecular Weight	206.26
Formula	C₈H₁₄O₄S
Cas No.	254737-29-6
Smiles	O=C(O)CCC(C(=O)O)CCCS
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8 mg/mL (38.79 mM), Sonication is recommended.

DMSO: 80 mg/mL (387.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8482 mL	24.2412 mL	48.4825 mL	242.4125 mL
5 mM	0.9696 mL	4.8482 mL	9.6965 mL	48.4825 mL
10 mM	0.4848 mL	2.4241 mL	4.8482 mL	24.2412 mL
20 mM	0.2424 mL	1.2121 mL	2.4241 mL	12.1206 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0970 mL	0.4848 mL	0.9696 mL	4.8482 mL
100 mM	0.0485 mL	0.2424 mL	0.4848 mL	2.4241 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc