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FM04

Name: FM04
Brand: TargetMol
SKU: T72055
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T72055Cas No. 1807320-40-6

FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.

FM04

🥰Excellent

Purity: 99.77%

Catalog No. T72055Cas No. 1807320-40-6

Pack Size	Price	Availability
1 mg	$82	In Stock
5 mg	$203	In Stock
10 mg	$291	In Stock
25 mg	$453	In Stock
50 mg	$667	In Stock
100 mg	$950	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.77%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.
Targets&IC50	P-gp:83 nM(EC50)
In vitro	FM04 (100 μM) exhibits competition with its photoaffinity derivative XC4 in LCC6MDR cells.[1] FM04 inhibits P-glycoprotein with an EC50=83 nM, where the EC50 value refers to the effective modulator concentration IC50 (=3.8 nM) that reduces paclitaxel (PTX) by half in the P-gp overexpressing cell line LCC6MDR.[1]

Chemical Properties

Molecular Weight	415.48
Formula	C₂₆H₂₅NO₄
Cas No.	1807320-40-6
Smiles	O=C1C=C(OC=2C1=CC=CC2)C3=CC=C(OCCOCCNCC4=CC=CC=C4)C=C3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (132.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4069 mL	12.0343 mL	24.0685 mL	120.3427 mL
5 mM	0.4814 mL	2.4069 mL	4.8137 mL	24.0685 mL
10 mM	0.2407 mL	1.2034 mL	2.4069 mL	12.0343 mL
20 mM	0.1203 mL	0.6017 mL	1.2034 mL	6.0171 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4069 mL
100 mM	0.0241 mL	0.1203 mL	0.2407 mL	1.2034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc