Shopping Cart

Your shopping cart is currently empty

FM04

Name: FM04
Brand: TargetMol
SKU: T72055
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T72055Cas No. 1807320-40-6

FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.

FM04

🥰Excellent

Purity: 99.87%

Catalog No. T72055Cas No. 1807320-40-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	In Stock	In Stock
5 mg	$203	In Stock	In Stock
10 mg	$291	In Stock	In Stock
25 mg	$453	In Stock	In Stock
50 mg	$667	In Stock	In Stock
100 mg	$950	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.
Targets&IC50	P-gp:83 nM(EC50)
In vitro	FM04 (100 μM) exhibits competition with its photoaffinity derivative XC4 in LCC6MDR cells.[1] FM04 inhibits P-glycoprotein with an EC50=83 nM, where the EC50 value refers to the effective modulator concentration IC50 (=3.8 nM) that reduces paclitaxel (PTX) by half in the P-gp overexpressing cell line LCC6MDR.[1]

Chemical Properties

Molecular Weight	415.48
Formula	C₂₆H₂₅NO₄
Cas No.	1807320-40-6
Smiles	O=C1C=C(OC=2C1=CC=CC2)C3=CC=C(OCCOCCNCC4=CC=CC=C4)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (132.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4069 mL	12.0343 mL	24.0685 mL	120.3427 mL
5 mM	0.4814 mL	2.4069 mL	4.8137 mL	24.0685 mL
10 mM	0.2407 mL	1.2034 mL	2.4069 mL	12.0343 mL
20 mM	0.1203 mL	0.6017 mL	1.2034 mL	6.0171 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4069 mL
100 mM	0.0241 mL	0.1203 mL	0.2407 mL	1.2034 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc