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Cyclooctyne-O-amido-PEG2-PFP ester

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Catalog No. T39539Cas No. 2101206-61-3
Alias Cyclooctyne-O-amido-PEG2-PFP ester

Cyclooctyne-O-amido-PEG2-PFP ester is a two-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs) as a non-cleavable linker.

Cyclooctyne-O-amido-PEG2-PFP ester

Cyclooctyne-O-amido-PEG2-PFP ester

😃Good
Catalog No. T39539Alias Cyclooctyne-O-amido-PEG2-PFP esterCas No. 2101206-61-3
Cyclooctyne-O-amido-PEG2-PFP ester is a two-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs) as a non-cleavable linker.
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Product Introduction

Bioactivity
Description
Cyclooctyne-O-amido-PEG2-PFP ester is a two-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs) as a non-cleavable linker.
In vitro
ADCs consist of an antibody linked to a cytotoxin via a specific (ADC linker)[1].
SynonymsCyclooctyne-O-amido-PEG2-PFP ester
Chemical Properties
Molecular Weight507.45
FormulaC23H26F5NO6
Cas No.2101206-61-3
SmilesFc1c(F)c(F)c(OC(=O)CCOCCOCCNC(=O)COC2CCCCCC#C2)c(F)c1F
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

Cyclooctyne-O-amido-PEG-2-PFP esterCyclooctyneOamidoPEG2PFP esterCyclooctyne O amido PEG2 PFP esterADCLinkerADC Linker
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