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OPC 8490 free base
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Catalog No. T33807LCas No. 106752-32-3
Alias OPC-8490 free base, OPC8490 free base
OPC 8490 free base is a novel positive inotropic vasodilator and a cardiotonic agent that increases Ca currents in a dose-dependent and reversible manner and can be used to study cardiovascular diseases.
OPC 8490 free base
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Purity: 99.53%
Catalog No. T33807LAlias OPC-8490 free base, OPC8490 free baseCas No. 106752-32-3
OPC 8490 free base is a novel positive inotropic vasodilator and a cardiotonic agent that increases Ca currents in a dose-dependent and reversible manner and can be used to study cardiovascular diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $117 | - | In Stock | |
| 5 mg | $290 | - | In Stock | |
| 10 mg | $415 | - | In Stock | |
| 25 mg | $648 | - | In Stock | |
| 50 mg | $893 | - | In Stock | |
| 100 mg | $1,180 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.53%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | OPC 8490 free base is a novel positive inotropic vasodilator and a cardiotonic agent that increases Ca currents in a dose-dependent and reversible manner and can be used to study cardiovascular diseases. |
| In vivo | OPC 8490 free base (0.1, 0.3, and 1 μM/kg) doses given to the jugular vein of supported dogs dose-dependently induced reductions in heart rate and arterial blood pressure in intact supported dogs; OPC 8490 free base (1 μM) temporally induced a three-phase, Ph1 followed by a Ph2 and slight positive (Ph3) time-varying effect and a positive inotropic effect. [1] |
| Synonyms | OPC-8490 free base, OPC8490 free base |
| Molecular Weight | 405.49 |
| Formula | C24H27N3O3 |
| Cas No. | 106752-32-3 |
| Smiles | O=C(C1=CC=C2NC(=O)CCC2=C1)N3CCN(CC3)CCCC(=O)C=4C=CC=CC4 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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