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SET 2

Name: SET 2
Brand: TargetMol
SKU: T37097
Price: 461 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37097Cas No. 2313525-20-9

SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.

SET 2

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Purity: 99.77%

Catalog No. T37097Cas No. 2313525-20-9

SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$53	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$187	In Stock	In Stock
50 mg	$316	In Stock	In Stock
100 mg	$461	-	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.
Targets&IC50	TRPV2:0.46 μM
In vitro	In PC-3M cells, SET 2 (20 μM) suppresses cell migration without inhibiting cell viability and inhibits 2-APB-evoked current transiently co-transfected with TRPV2 and LPAR1[1].

Chemical Properties

Molecular Weight	402.43
Formula	C₁₇H₂₁F₃N₄O₂S
Cas No.	2313525-20-9
Smiles	CCCN(C)c1cc(nc(SCCC(=O)NCc2ccco2)n1)C(F)(F)F

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (124.25 mM), Sonication is recommended.

Ethanol: 20.12 mg/mL (50 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4849 mL	12.4245 mL	24.8490 mL	124.2452 mL
5 mM	0.4970 mL	2.4849 mL	4.9698 mL	24.8490 mL
10 mM	0.2485 mL	1.2425 mL	2.4849 mL	12.4245 mL
20 mM	0.1242 mL	0.6212 mL	1.2425 mL	6.2123 mL
50 mM	0.0497 mL	0.2485 mL	0.4970 mL	2.4849 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0248 mL	0.1242 mL	0.2485 mL	1.2425 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc