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PF-04856264
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Catalog No. T33943Cas No. 1235397-05-3
Alias PF-4856264, PF4856264, PF04856264
PF-04856264 is a Nav1.7 blocker.Nav1.7 is a chondrocyte modulator and a therapeutic target in osteoarthritis.Inhibition of Nav1.7 modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain and inhibits ERK expression, which has analgesic and anti-inflammatory effects.
PF-04856264
😃Good
Catalog No. T33943Alias PF-4856264, PF4856264, PF04856264Cas No. 1235397-05-3
PF-04856264 is a Nav1.7 blocker.Nav1.7 is a chondrocyte modulator and a therapeutic target in osteoarthritis.Inhibition of Nav1.7 modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain and inhibits ERK expression, which has analgesic and anti-inflammatory effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $89 | 5 days |
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Product Introduction
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Chemical Properties
| Description | PF-04856264 is a Nav1.7 blocker.Nav1.7 is a chondrocyte modulator and a therapeutic target in osteoarthritis.Inhibition of Nav1.7 modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain and inhibits ERK expression, which has analgesic and anti-inflammatory effects. |
| Targets&IC50 | Nav1.7 (human):28 nM, Nav1.7 (dog):42 nM, Nav1.7 (mouse):131 nM |
| In vivo | Methods: PF-04856264 (3-30 mg/kg, intraperitoneal injection) was used to treat the OD1-induced spontaneous pain model in adult male C57BL/6J mice to observe its therapeutic effect. Results: PF-04856264 significantly reduced the spontaneous pain behavior of mice. [2] |
| Alias | PF-4856264, PF4856264, PF04856264 |
| Molecular Weight | 437.5 |
| Formula | C20H15N5O3S2 |
| Cas No. | 1235397-05-3 |
| Smiles | N#CC1=CC(=CC=C1OC=2C=CC=CC2C3=CC=NN3C)S(=O)(=O)NC4=NC=CS4 |
| Relative Density. | 1.44 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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