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Saccharic acid

Name: Saccharic acid
Brand: TargetMol
SKU: T201826
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T201826 Copy Product Info

Purity: 99.89%

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Saccharic acid (also known as glucaric acid) is a dicarboxylic acid formed by the oxidation of glucose, and it is an important intermediate in the study of sugar metabolism and carbohydrate oxidation. It acts as a competitive inhibitor of β-glucuronidase, preventing the hydrolysis of glucuronides that have already bound to toxins, thereby blocking the regeneration of toxic complexes.

Cas No. 87-73-0

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$31	-	In Stock
100 mg	$52	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Saccharic acid (also known as glucaric acid) is a dicarboxylic acid formed by the oxidation of glucose, and it is an important intermediate in the study of sugar metabolism and carbohydrate oxidation. It acts as a competitive inhibitor of β-glucuronidase, preventing the hydrolysis of glucuronides that have already bound to toxins, thereby blocking the regeneration of toxic complexes.
In vitro	Saccharic acid (50 µM Fe(III)-saccharic acid + 90 min UV-C irradiation) enhances the photofenton degradation of methylene blue [1]. Saccharic acid (50–150 × 10^(−4) M; 1 h) potently, competitively, and reversibly inhibits β-glucuronidase activity in mouse liver and kidney [2]. Saccharic acid (1 × 10^(−3) M; 2 h) strongly inhibits the hydrolysis of o-aminophenyl-glucuronide by mouse liver β-glucuronidase preparations [2]. Saccharic acid (0.01 M; 90 min) reduces β-glucuronidase activity in intact mouse liver sections [2].
In vivo	Saccharic acid (5 g/kg; subcutaneous injection; administered daily; continued until day 8) does not alter the liver regeneration process following carbon tetrachloride-induced injury or partial hepatectomy [2]. Saccharic acid (2 g/kg; intraperitoneal injection; daily; 3 weeks) or (3%; dietary supplementation; ad libitum; 3 weeks) does not alter normal growth in young mice [2].

Chemical Properties

Molecular Weight	210.139
Formula	C₆H₁₀O₈
Cas No.	87-73-0
Smiles	OC([C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200.00 mg/mL (951.75 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.7588 mL	23.7938 mL	47.5875 mL	237.9377 mL
5 mM	0.9518 mL	4.7588 mL	9.5175 mL	47.5875 mL
10 mM	0.4759 mL	2.3794 mL	4.7588 mL	23.7938 mL
20 mM	0.2379 mL	1.1897 mL	2.3794 mL	11.8969 mL
50 mM	0.0952 mL	0.4759 mL	0.9518 mL	4.7588 mL
100 mM	0.0476 mL	0.2379 mL	0.4759 mL	2.3794 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Saccharic acid chemical structure | Saccharic acid in vivo | Saccharic acid in vitro | Saccharic acid formula | Saccharic acid molecular weight