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DL-AP5 lithium
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Catalog No. T201724Cas No. 125229-62-1
Alias DL-2-Amino-5-phosphonovaleric acid lithium, 2-APV lithium
DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina.
DL-AP5 lithium
😃Good
Catalog No. T201724Alias DL-2-Amino-5-phosphonovaleric acid lithium, 2-APV lithiumCas No. 125229-62-1
DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina. |
| In vitro | DL-AP5 (100 μM) mitigates the elevation of Arc/Arg3.1 protein levels caused by glutamate exposure and reduces NMDA-induced upregulation of Arc/Arg3.1. |
| In vivo | DL-AP5, when administered intra-CA1 (0-10 μg/rat), significantly diminishes NMDA's effects. At a range of 0-10 nmol via intracerebroventricular injection, it elicits a dose-dependent escalation in food intake. Moreover, a specific dose of 5 nmol of DL-AP5 via the same route effectively mitigates the reduction in food consumption that is typically prompted by an intracerebroventricular injection of ghrelin. |
| Synonyms | DL-2-Amino-5-phosphonovaleric acid lithium, 2-APV lithium |
| Molecular Weight | 203.06 |
| Formula | C5H11LiNO5P |
| Cas No. | 125229-62-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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