Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 430.00 | |
10 mg | In stock | $ 636.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,360.00 | |
100 mg | In stock | $ 1,830.00 | |
500 mg | In stock | $ 3,680.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 468.00 |
Description | PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively. |
Targets&IC50 | PI5P4Kα:<4.3(pIC50), PI5P4Kβ:<4.6(pIC50), PI5P4Kγ:6.2(pIC50), PI5P4Kγ+:0.32(pIC50), PI5P4Kγ (WT):68 nM(Ki), PI5P4Kβ:>30 μM(Ki) |
In vitro | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
In vivo | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
Molecular Weight | 357.45 |
Formula | C22H23N5 |
CAS No. | 2766854-03-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (72.08 mM)
You can also refer to dose conversion for different animals. More
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PI5P4Ks-IN-2 2766854-03-7 PI3K/Akt/mTOR signaling PI3K PI5P4KsIN2 inhibitor inhibit