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Pyronaridine tetraphosphate

Name: Pyronaridine tetraphosphate
Brand: TargetMol
SKU: T16697
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16697Cas No. 76748-86-2

Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections. Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections and attenuates Ebola virus transmission.

Pyronaridine tetraphosphate

🥰Excellent

Purity: 99.82%

Catalog No. T16697Cas No. 76748-86-2

Pack Size	Price	Availability	Quantity
10 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Purity:99.82%

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COA HNMR PNMR HPLC

Product Introduction

Bioactivity

Description	Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections. Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections and attenuates Ebola virus transmission.
Targets&IC50	P. falciparum:1.53-3.94 nM
In vitro	With an IC50 value of 1.53-3.94 nM, pyronaridine tetraphosphate (24 h) exhibits anti-P. falciparum activity[2].
In vivo	Reducing the parasitic burden in Echinococcus granulosus-infected mice, pyronaridine tetraphosphate (57 mg/kg, oral administration, q.d. for 30 days) has been demonstrated[1].Reducing the parasitic burden in secondarily infected (cysts) mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, q.d. for 3 days) has shown efficacy[1].Exhibiting a higher exposure in the liver than in the plasma in male ICR mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, for a single dose) has been observed[1].

Chemical Properties

Molecular Weight	910.03
Formula	C₂₉H₄₄ClN₅O₁₈P₄
Cas No.	76748-86-2
Smiles	O=P(O)(O)O.ClC(C=CC1=C2NC3=CC(CN4CCCC4)=C(O)C(CN5CCCC5)=C3)=CC1=NC6=C2N=C(OC)C=C6.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O
Relative Density.	1.357g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (21.98 mM), Sonication is recommended.

DMSO: 10 mg/mL (10.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.0989 mL	5.4943 mL	10.9886 mL	54.9432 mL
5 mM	0.2198 mL	1.0989 mL	2.1977 mL	10.9886 mL
10 mM	0.1099 mL	0.5494 mL	1.0989 mL	5.4943 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0549 mL	0.2747 mL	0.5494 mL	2.7472 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc