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2',4'-DIHYDROXYCHALCONE
🥰Excellent
Catalog No. T8829Cas No. 1776-30-3
Alias 2',4'-DHC
2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects
2',4'-DIHYDROXYCHALCONE
🥰Excellent
Purity: 98.95%
Catalog No. T8829Alias 2',4'-DHCCas No. 1776-30-3
2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $156 | In Stock | |
| 50 mg | $247 | In Stock | |
| 100 mg | $372 | In Stock | |
| 200 mg | $548 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $59 | In Stock |
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Purity:98.95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects |
| In vitro | In the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.?The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC.?The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced.?The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin.?Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90.?2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor[1]. |
| Synonyms | 2',4'-DHC |
| Molecular Weight | 240.25 |
| Formula | C15H12O3 |
| Cas No. | 1776-30-3 |
| Smiles | Oc1ccc(C(=O)C=Cc2ccccc2)c(O)c1 |
| Relative Density. | 1.286g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (45.79 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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