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Carbidopa
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Catalog No. T6795Cas No. 28860-95-9
Alias Lodosyn, (S)-(-)-Carbidopa
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.
Carbidopa
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Purity: 99.64%
Catalog No. T6795Alias Lodosyn, (S)-(-)-CarbidopaCas No. 28860-95-9
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $33 | In Stock | In Stock | |
| 10 mg | $48 | In Stock | In Stock | |
| 25 mg | $63 | In Stock | In Stock | |
| 50 mg | $77 | In Stock | In Stock | |
| 100 mg | $93 | In Stock | In Stock | |
| 500 mg | $240 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.64%
Color:White
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Product Introduction
Carbidopa AI Summary
Carbidopa demonstrates a wide range of bioactivities with particularly varied inhibitory effects on multiple enzymes and biological processes. It exhibits inhibitory activity in the nanomolar range against enzymes such as histone lysine methyltransferases, glutaminase, and phosphofructokinase and impacts processes like the proliferation of Plasmodium falciparum, splicing modulation, and DNA repair. It also affects viral enzymes, notably SARS-CoV-2 3CL-Pro protease, with an inhibition percentage of 96.46% at 20 µM and an IC50 value of 3550.0 nM.
The compound shows potential antiviral activity, inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and Vero-6 cells, although with relatively low potency. It significantly reduces cell viability in Hep3B cells through CYP-mediated drug metabolism. Additionally, compound 675187 has weak inhibitory effects on the bile salt export pump (BSEP) and multidrug resistance-related proteins (MRP2, MRP3, MRP4) in membrane vesicle transport assays.
In pharmacokinetic assessments, compound 675187 exhibits a LogD7.4 value of -0.7, indicating its hydrophobic nature. It also induces drug-induced liver injury (DILI) in humans, classified as severity level 3. Despite its broad spectrum of activity, the inhibitory effects on human HDAC6 and its antiviral activity against MERS 3CL-Pro protease appear limited..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. |
| Targets&IC50 | Aromatic-L-amino-acid decarboxylase:29 μM |
| Synonyms | Lodosyn, (S)-(-)-Carbidopa |
| Molecular Weight | 226.23 |
| Formula | C10H14N2O4 |
| Cas No. | 28860-95-9 |
| Smiles | [C@@](CC1=CC(O)=C(O)C=C1)(C(O)=O)(NN)C |
| Relative Density. | 1.42 g/cm3 |
| Storage | keep away from direct sunlight,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (19.89 mM), Sonication is recommended. | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.42 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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