Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 μg/ml).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | 35 days | $ 218.00 | |
1 g | 35 days | $ 294.00 | |
5 g | 35 days | $ 1,380.00 |
Description | Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 μg/ml). |
Molecular Weight | 1021.85 |
Formula | C12H22KO35S8 |
CAS No. | 73264-44-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL
You can also refer to dose conversion for different animals. More
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Sucrose octasulfate (potassium salt) 73264-44-5 Sucrose Sucrose Octasulfate inhibitor inhibit