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Manool

🥰Excellent
Catalog No. T78479Cas No. 596-85-0

Manool, a diterpene from Salvia miltiorrhiza, showed antitumor activity in a mouse melanoma model.Manool caused cell cycle arrest in the G(2)/M phase of cancer cells, reducing the prevention of chromosomal damage and precancerous lesions.Manool induced endothelium-independent vasorelaxation mediated by the NO/cGMP signaling pathway in rat aorta and lowered blood pressure.

Manool

Manool

🥰Excellent
Purity: 99.88%
Catalog No. T78479Cas No. 596-85-0
Manool, a diterpene from Salvia miltiorrhiza, showed antitumor activity in a mouse melanoma model.Manool caused cell cycle arrest in the G(2)/M phase of cancer cells, reducing the prevention of chromosomal damage and precancerous lesions.Manool induced endothelium-independent vasorelaxation mediated by the NO/cGMP signaling pathway in rat aorta and lowered blood pressure.
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2 mg$37In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.88%
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Product Introduction

Bioactivity
Description
Manool, a diterpene from Salvia miltiorrhiza, showed antitumor activity in a mouse melanoma model.Manool caused cell cycle arrest in the G(2)/M phase of cancer cells, reducing the prevention of chromosomal damage and precancerous lesions.Manool induced endothelium-independent vasorelaxation mediated by the NO/cGMP signaling pathway in rat aorta and lowered blood pressure.
In vitro
Manool exhibits higher cytotoxic activity against HeLa and U343 cells, with an IC50 of 6.7 µg/mL for both.[1]
Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells.[3]
Chemical Properties
Molecular Weight290.48
FormulaC20H34O
Cas No.596-85-0
SmilesC[C@@]12[C@](C(C)(C)CCC1)(CCC(=C)[C@@H]2CC[C@@](C=C)(C)O)[H]
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (275.41 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.36 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4426 mL17.2129 mL34.4258 mL172.1289 mL
5 mM0.6885 mL3.4426 mL6.8852 mL34.4258 mL
10 mM0.3443 mL1.7213 mL3.4426 mL17.2129 mL
20 mM0.1721 mL0.8606 mL1.7213 mL8.6064 mL
50 mM0.0689 mL0.3443 mL0.6885 mL3.4426 mL
100 mM0.0344 mL0.1721 mL0.3443 mL1.7213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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