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Vimnerixin

Name: Vimnerixin
Brand: TargetMol
SKU: T38850
Price: 399 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38850Cas No. 1418112-77-2

Alias RIST4721, RIST 4721, AZD4721, AZD 4721

Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.

Vimnerixin

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Purity: 99.52%

Catalog No. T38850Alias RIST4721, RIST 4721, AZD4721, AZD 4721Cas No. 1418112-77-2

Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$399	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.
In vitro	Vimnerixin (RIST4721) inhibited KC-stimulated chemotaxis in a dose-dependent manner. Vimnerixin at 10 nM and 100 nM significantly suppressed chemotaxis, while the inhibitory effect at 1 nM was not evident. Vimnerixin at 1 μM completely blocked KC-induced chemotaxis.
In vivo	In preclinical studies, Vimnerixin underwent systematic pharmacokinetic evaluation in male Sprague-Dawley (SD) rats and beagle dogs via intravenous injection (1 mg/kg) and oral administration, with bile duct cannulation (BDC) experiments conducted to assess its excretion pathways. The results demonstrated that Vimnerixin exhibited low clearance rates (2.4 ml/min/kg in rats, 0.5 ml/min/kg in dogs), low volume of distribution (0.15–0.19 L/kg), and prolonged half-life (3.7 hours for intravenous administration in dogs, extending to 8.4 hours for oral administration). The plasma concentration-time curves were highly consistent between bile-duct-cannulated and non-cannulated groups, indicating minimal influence from enterohepatic circulation.
Synonyms	RIST4721, RIST 4721, AZD4721, AZD 4721

Chemical Properties

Molecular Weight	472.55
Formula	C₁₉H₂₅FN₄O₅S₂
Cas No.	1418112-77-2
Smiles	N(S(=O)(=O)N1CC(C)C1)C=2C=C(O[C@@H]([C@H](CO)O)C)N=C(SCC3=CC=C(F)C=C3)N2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (169.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1162 mL	10.5809 mL	21.1618 mL	105.8089 mL
5 mM	0.4232 mL	2.1162 mL	4.2324 mL	21.1618 mL
10 mM	0.2116 mL	1.0581 mL	2.1162 mL	10.5809 mL
20 mM	0.1058 mL	0.5290 mL	1.0581 mL	5.2904 mL
50 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1162 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc