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Cofrogliptin

Name: Cofrogliptin
Brand: TargetMol
SKU: T62985
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62985Cas No. 1844874-26-5

Alias HSK-7653, HSK7653, HSK 7653

Cofrogliptin (HSK7653) is an orally available dipeptidyl peptidase-4 (DPP-4) inhibitor with hypoglycemic effects, which can be used to study type 2 diabetes (T2D).

Cofrogliptin

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Purity: 99.25%

Catalog No. T62985Alias HSK-7653, HSK7653, HSK 7653Cas No. 1844874-26-5

Cofrogliptin (HSK7653) is an orally available dipeptidyl peptidase-4 (DPP-4) inhibitor with hypoglycemic effects, which can be used to study type 2 diabetes (T2D).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$172	-	In Stock
10 mg	$277	-	In Stock
25 mg	$556	-	In Stock
50 mg	$893	-	In Stock
1 mL x 10 mM (in DMSO)	$176	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.25%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Cofrogliptin (HSK7653) is an orally available dipeptidyl peptidase-4 (DPP-4) inhibitor with hypoglycemic effects, which can be used to study type 2 diabetes (T2D).
Targets&IC50	DPP4:4.2 nM
In vitro	Evaluate the DPP-4 inhibitory activities of Cofrogliptin, Cofrogliptin exhibited a much better in vitro activity, which significantly enhanced the potency IC50 = 4.2 nM. [1]
In vivo	In vehicle group, mice were intragastrically given 1% hypromellose at a volume of 20 mL/kg. In treatment groups, mice were intragastrically administrated either omarigliptin at 30 mg/kg or varying doses of Cofrogliptin. Cofrogliptin inhibitory activity on plasma DPP-4 was assayed ex vivo in ob/ob mice. After a single dose, Cofrogliptin exhibited a much stronger inhibition capability of plasma DPP-4 than omarigliptin in a dose dependent manner. Monkeys were intragastrically administrated either vehicle or Cofrogliptin (10 mg/kg) at a volume of 5 mL/kg. The ex vivo plasma DPP-4 inhibition was also assayed for Cofrogliptin in rhesus monkeys. After a single dose of 10 mg/kg, Cofrogliptin possessed the capability of plasma DPP-4 inhibition over 80% for at least 12 days. [1]
Synonyms	HSK-7653, HSK7653, HSK 7653

Chemical Properties

Molecular Weight	466.43
Formula	C₁₈H₁₉F₅N₄O₃S
Cas No.	1844874-26-5
Smiles	C(F)(F)(F)[C@@H]1[C@@H](C[C@H](N)[C@H](O1)C2=C(F)C=CC(F)=C2)N3CC=4C(C3)=NN(S(C)(=O)=O)C4

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (171.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1439 mL	10.7197 mL	21.4394 mL	107.1972 mL
5 mM	0.4288 mL	2.1439 mL	4.2879 mL	21.4394 mL
10 mM	0.2144 mL	1.0720 mL	2.1439 mL	10.7197 mL
20 mM	0.1072 mL	0.5360 mL	1.0720 mL	5.3599 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	2.1439 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc