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EIT hydrobromide

Name: EIT hydrobromide
Brand: TargetMol
SKU: T22761
Rating: 4.5 (1 reviews)

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Catalog No. T22761Cas No. 1071-37-0

Alias S-Ethylisothiourea hydrobromide, 2-Ethyl-2-thiopseudourea hydrobromide

EIT hydrobromide (S-Ethylisothiourea hydrobromide) is an iNOS inhibitor.

EIT hydrobromide

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Purity: 99.81%

Catalog No. T22761Alias S-Ethylisothiourea hydrobromide, 2-Ethyl-2-thiopseudourea hydrobromideCas No. 1071-37-0

EIT hydrobromide (S-Ethylisothiourea hydrobromide) is an iNOS inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	4-6 weeks	4-6 weeks
1 mL x 10 mM (in DMSO)	$50	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

EIT hydrobromide AI Summary

EIT hydrobromide exhibits a diverse range of bioactivities. It induces the erasure of genomic imprints with a potency of 6309.6 nM and inhibits several enzymes, including Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 3548.1 nM, Bloom's syndrome helicase (BLM) with a potency of 2.8 nM, GCN5L2 with a potency of 31622.8 nM, and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with a potency of 12589.3 nM. Additionally, it serves as a differential inhibitor of proliferation of Plasmodium falciparum with a potency of 22387.2 nM and acts as a delayed death inhibitor of the malarial parasite plastid with a potency of 3696.4 nM. It also inhibits binding or entry into cells for Marburg Virus with a potency of 23099.9 nM. In terms of antiviral activity, EIT hydrobromide inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 25.71% at 10 µM after 48 hours and inhibits the SARS-CoV-2 3CL-Pro protease by 11.88% at 20 µM. However, the inhibition rate in VERO-6 cells is lower, showing 0.41% inhibition at 10 µM after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	EIT hydrobromide (S-Ethylisothiourea hydrobromide) is an iNOS inhibitor.
Synonyms	S-Ethylisothiourea hydrobromide, 2-Ethyl-2-thiopseudourea hydrobromide

Chemical Properties

Molecular Weight	185.09
Formula	C₃H₉BrN₂S
Cas No.	1071-37-0
Smiles	Br.CCSC(N)=N
Relative Density.	1.19 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (324.17 mM), Sonication is recommended.

H2O: ≥7.85 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4028 mL	27.0139 mL	54.0278 mL	270.1389 mL
5 mM	1.0806 mL	5.4028 mL	10.8056 mL	54.0278 mL
10 mM	0.5403 mL	2.7014 mL	5.4028 mL	27.0139 mL
20 mM	0.2701 mL	1.3507 mL	2.7014 mL	13.5069 mL
50 mM	0.1081 mL	0.5403 mL	1.0806 mL	5.4028 mL
100 mM	0.0540 mL	0.2701 mL	0.5403 mL	2.7014 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc