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AZD-4877

Name: AZD-4877
Brand: TargetMol
SKU: T9682
Price: 137 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9682Cas No. 758722-49-5

Alias AZD4877

AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).

AZD-4877

🥰Excellent

Purity: 99.75%

Catalog No. T9682Alias AZD4877Cas No. 758722-49-5

Pack Size	Price	Availability
1 mg	$137	In Stock
5 mg	$318	In Stock
10 mg	$475	In Stock
25 mg	$857	In Stock
50 mg	$1,280	In Stock
100 mg	$1,930	In Stock
200 mg	$2,580	In Stock
1 mL x 10 mM (in DMSO)	$352	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.75%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).
Targets&IC50	EG5:2 nM
Synonyms	AZD4877

Chemical Properties

Molecular Weight	503.66
Formula	C₂₈H₃₃N₅O₂S
Cas No.	758722-49-5
Smiles	C(N(C(=O)C1=CC=C(C)C=C1)CCCN)(C(C)C)C=2N(CC3=CC=CC=C3)C(=O)C4=C(N2)SN=C4C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (109.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9855 mL	9.9273 mL	19.8547 mL	99.2733 mL
5 mM	0.3971 mL	1.9855 mL	3.9709 mL	19.8547 mL
10 mM	0.1985 mL	0.9927 mL	1.9855 mL	9.9273 mL
20 mM	0.0993 mL	0.4964 mL	0.9927 mL	4.9637 mL
50 mM	0.0397 mL	0.1985 mL	0.3971 mL	1.9855 mL
100 mM	0.0199 mL	0.0993 mL	0.1985 mL	0.9927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc