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CD32B Protein, Mouse, Recombinant (His)

Catalog No. TMPJ-00803
Synonyms: Fcgr2, Fcgr2b, Fc-γ-RIIB, Fc-γ RII, Low affinity immunoglobulin γ Fc region receptor II, Fc gamma receptor IIB, Low affinity immunoglobulin gamma Fc region receptor II, Fc γ receptor IIB, Ly-17, Fc-gamma RII, FcRII, IgG Fc receptor II beta, CD32, IgG Fc receptor II β, Lymphocyte antigen 17, Fc-gamma-RIIB

Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD32B Protein, Mouse, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 116.00
50 μg 5 days $ 310.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.
Species Mouse
Expression System Human Cells
Tag C-6His
Accession Number P08101
Synonyms Fcgr2, Fcgr2b, Fc-γ-RIIB, Fc-γ RII, Low affinity immunoglobulin γ Fc region receptor II, Fc gamma receptor IIB, Low affinity immunoglobulin gamma Fc region receptor II, Fc γ receptor IIB, Ly-17, Fc-gamma RII, FcRII, IgG Fc receptor II beta, CD32, IgG Fc receptor II β, Lymphocyte antigen 17, Fc-gamma-RIIB
Amino Acid Thr30-Pro210
Construction Recombinant Mouse Low Affinity Immunoglobulin Gamma Fc Region Receptor II is produced by our Mammalian expression system and the target gene encoding Thr30-Pro210 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 33 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.

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Keywords

CD32B Protein, Mouse, Recombinant (His) Fcgr2 Fcgr2b CD 32 CD-32 Fc-γ-RIIB Fc-γ RII Low affinity immunoglobulin γ Fc region receptor II Fc gamma receptor IIB Low affinity immunoglobulin gamma Fc region receptor II Fc γ receptor IIB Ly-17 Fc-gamma RII FcRII IgG Fc receptor II beta CD32 IgG Fc receptor II β Lymphocyte antigen 17 Fc-gamma-RIIB recombinant recombinant-proteins proteins protein

 

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