CD32B/Fcgr2b Protein, Mouse, Recombinant (His)

Catalog No. TMPJ-00803

Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.

CD32B/Fcgr2b Protein, Mouse, Recombinant (His)

Catalog No. TMPJ-00803

Pack Size	Price	Availability
5 μg	$72	7-10 days
10 μg	$116	7-10 days
20 μg	$176	7-10 days
50 μg	$310	7-10 days
100 μg	$532	7-10 days
200 μg	$919	7-10 days
500 μg	$1,900	7-10 days
1 mg	$2,730	7-10 days

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Product Information

Biological Activity	Loaded Mouse CD32-His on HIS1K Biosensor, can bind Anti-Human HER2 mAb with an affinity constant of 1.14 uM as determined in BLI assay. (Regularly tested)
Description	Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	P08101
Synonyms	Lymphocyte antigen 17,Ly-17,Low affinity immunoglobulin γ Fc region receptor II,Low affinity immunoglobulin gamma Fc region receptor II,IgG Fc receptor II β,IgG Fc receptor II beta,Fc-γ-RIIB,Fc-γ RII,FcRII,Fcgr2b,Fcgr2,Fc-gamma-RIIB,Fc-gamma RII,Fc γ receptor IIB,Fc gamma receptor IIB,CD32
Amino Acid	Thr30-Pro210
Construction	Thr30-Pro210
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	33 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.