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JNJ-9676

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Catalog No. T205924Cas No. 3026520-19-1
Alias JNJ9676

JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, which binds to the membrane protein dimer's transmembrane domain-formed binding pocket, thereby blocking viral assembly and release. It exhibits nanomolar-level antiviral activity against the novel coronavirus and SARS-CoV.

JNJ-9676

JNJ-9676

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Purity: 99.83%
Catalog No. T205924Alias JNJ9676Cas No. 3026520-19-1
JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, which binds to the membrane protein dimer's transmembrane domain-formed binding pocket, thereby blocking viral assembly and release. It exhibits nanomolar-level antiviral activity against the novel coronavirus and SARS-CoV.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$147-In Stock
5 mg$367-In Stock
10 mg$591-In Stock
25 mg$1,230-In Stock
50 mg$1,930-In Stock
100 mg$2,880-In Stock
1 mL x 10 mM (in DMSO)$393-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.83%
ee:100%
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COA HNMR CSFC FNMR ORP LCMS

Product Introduction

Bioactivity
Description
JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, which binds to the membrane protein dimer's transmembrane domain-formed binding pocket, thereby blocking viral assembly and release. It exhibits nanomolar-level antiviral activity against the novel coronavirus and SARS-CoV.
SynonymsJNJ9676
Chemical Properties
Molecular Weight497.5
FormulaC28H21F2N5O2
Cas No.3026520-19-1
SmilesC(NC1=CC(C#N)=CC=C1)(=O)C2=C3N(C[C@H](C)N(C3=O)C4=CC=C(C(F)(F)C5=CC=CC=C5)C=C4)N=C2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 180 mg/mL (361.81 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (10.05 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0101 mL10.0503 mL20.1005 mL100.5025 mL
5 mM0.4020 mL2.0101 mL4.0201 mL20.1005 mL
10 mM0.2010 mL1.0050 mL2.0101 mL10.0503 mL
20 mM0.1005 mL0.5025 mL1.0050 mL5.0251 mL
50 mM0.0402 mL0.2010 mL0.4020 mL2.0101 mL
100 mM0.0201 mL0.1005 mL0.2010 mL1.0050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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