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Patamostat HCl

Catalog No. T9670L CAS 3031765-17-7

Synonyms: Patamostat HCl（114568-26-2 Free base）

Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.

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Patamostat HCl, CAS 3031765-17-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 465.00
10 mg	In stock	$ 679.00
25 mg	In stock	$ 1,070.00
50 mg	In stock	$ 1,430.00
100 mg	In stock	$ 1,930.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.
Targets&IC50	Thrombin:1.9 μM, Plasmin:950 nM, Trypsin:39 nM
In vivo	In rats or rabbits, Patamostat (intravenous infusion) at doses of 0.03-0.3 mg/kg or 0.3-3.0 mg/kg, respectively, reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].In dogs with pancreatitis, Patamostat (intravenous infusion) at doses of 1.0-3.0 mg/kg reduces the increases of serum trypsin and lipase activities[1].In male Wistar rats, continuous infusion of Patamostat (2 mg/kg per h) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme[2].

Synonyms	Patamostat HCl（114568-26-2 Free base）
Molecular Weight	448.92
Formula	C20H21ClN4O4S
CAS No.	3031765-17-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (111.38 mM)

References and Literature

1. T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9. 2. K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

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Related compounds with same targets

PF-3644022 FK706 BCX 1470 Benzamidine hydrochloride UK-371804 HCl BCX 1470 hydrochloride 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one Demethylwedelolactone

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Patamostat HCl 3031765-17-7 Proteases/Proteasome Serine Protease Protease Patamostat HCl（114568-26-2 Free base） 114568-26-2 Free base 114568-26-2 inhibitor inhibit

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