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Patamostat HCl

Name: Patamostat HCl
Brand: TargetMol
SKU: T9670L
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9670LCas No. 3031765-17-7

Alias Patamostat HCl(114568-26-2 Free base)

Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.

Patamostat HCl

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Purity: 99.15%

Catalog No. T9670LAlias Patamostat HCl(114568-26-2 Free base)Cas No. 3031765-17-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$279	-	In Stock
10 mg	$407	-	In Stock
25 mg	$642	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.15%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.
Targets&IC50	Thrombin:1.9 μM, Trypsin:39 nM, Plasmin:950 nM
In vivo	In rats or rabbits, Patamostat (intravenous infusion) at doses of 0.03-0.3 mg/kg or 0.3-3.0 mg/kg, respectively, reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].In dogs with pancreatitis, Patamostat (intravenous infusion) at doses of 1.0-3.0 mg/kg reduces the increases of serum trypsin and lipase activities[1].In male Wistar rats, continuous infusion of Patamostat (2 mg/kg per h) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme[2].
Synonyms	Patamostat HCl(114568-26-2 Free base)

Chemical Properties

Molecular Weight	448.92
Formula	C₂₀H₂₁ClN₄O₄S
Cas No.	3031765-17-7
Smiles	O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(C=C2)SCCN3C(CCC3=O)=O.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (111.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2276 mL	11.1378 mL	22.2757 mL	111.3784 mL
5 mM	0.4455 mL	2.2276 mL	4.4551 mL	22.2757 mL
10 mM	0.2228 mL	1.1138 mL	2.2276 mL	11.1378 mL
20 mM	0.1114 mL	0.5569 mL	1.1138 mL	5.5689 mL
50 mM	0.0446 mL	0.2228 mL	0.4455 mL	2.2276 mL
100 mM	0.0223 mL	0.1114 mL	0.2228 mL	1.1138 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc