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AMP-Deoxynojirimycin

Name: AMP-Deoxynojirimycin
Brand: TargetMol
SKU: T35626
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35626Cas No. 216758-20-2

Alias AMP-DNM

AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2, as well as GlcCer biosynthesis, and is utilized in the study of Parkinson's disease and diabetes.

AMP-Deoxynojirimycin

🥰Excellent

Catalog No. T35626Alias AMP-DNMCas No. 216758-20-2

AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2, as well as GlcCer biosynthesis, and is utilized in the study of Parkinson's disease and diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$413	-	In Stock
10 mg	$589	-	In Stock
25 mg	$939	-	In Stock
50 mg	$1,260	-	In Stock
100 mg	$1,680	-	In Stock
200 mg	$2,280	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2, as well as GlcCer biosynthesis, and is utilized in the study of Parkinson's disease and diabetes.
In vitro	In 3T3-L1 cells, AMP-Deoxynojirimycin (10 μM) significantly inhibits the leucine and C17ISO-induced phosphorylation of P70S6K[2].
Synonyms	AMP-DNM

Chemical Properties

Molecular Weight	397.55
Formula	C₂₂H₃₉NO₅
Cas No.	216758-20-2
Smiles	C(OCCCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1)C23CC4CC(C2)CC(C3)C4
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (100.62 mM), Sonication is recommended.

DMF: 50 mg/mL (125.77 mM), Sonication is recommended.

Ethanol: 20 mg/mL (50.31 mM), Sonication is recommended.

Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL (1.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.03 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
5 mM	0.5031 mL	2.5154 mL	5.0308 mL	25.1541 mL
10 mM	0.2515 mL	1.2577 mL	2.5154 mL	12.5770 mL
20 mM	0.1258 mL	0.6289 mL	1.2577 mL	6.2885 mL
50 mM	0.0503 mL	0.2515 mL	0.5031 mL	2.5154 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
100 mM	0.0252 mL	0.1258 mL	0.2515 mL	1.2577 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc