Shopping Cart

Your shopping cart is currently empty

GRK6-IN-2

Name: GRK6-IN-2
Brand: TargetMol
SKU: T61556
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T61556Cas No. 2677786-27-3

GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.

GRK6-IN-2

Copy Product Info

😃Good

Purity: 98.94%

Catalog No. T61556Cas No. 2677786-27-3

GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$56	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$322	In Stock	In Stock
50 mg	$497	In Stock	In Stock
100 mg	$747	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.94%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

GRK6-IN-2 AI Summary

GRK6-IN-2 exhibits bioactivities related to inhibiting the activity of certain proteins. It inhibits recombinant full-length human GRK6 with an IC50 of 120.0 nM and recombinant full-length human Aurora A with an IC50 of 11.0 nM. These activities suggest that GRK6-IN-2 may have potential as a kinase inhibitor in cellular pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.

Chemical Properties

Molecular Weight	376.43
Formula	C₂₁H₂₁FN₆
Cas No.	2677786-27-3
Smiles	CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3ccccc23)n[nH]1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (119.54 mM), Sonication is recommended.

Methanol: 80 mg/mL (212.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	2.6565 mL	13.2827 mL	26.5654 mL	132.8268 mL
5 mM	0.5313 mL	2.6565 mL	5.3131 mL	26.5654 mL
10 mM	0.2657 mL	1.3283 mL	2.6565 mL	13.2827 mL
20 mM	0.1328 mL	0.6641 mL	1.3283 mL	6.6413 mL
50 mM	0.0531 mL	0.2657 mL	0.5313 mL	2.6565 mL
100 mM	0.0266 mL	0.1328 mL	0.2657 mL	1.3283 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc