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Dehydrocurdione
Catalog No. TN6867 Copy Product Info
Purity: 98.86%
🥰Excellent
Dehydrocurdione is a sesquiterpene derived from zedoary with potent anti-inflammatory and antioxidant properties. It functions as a specialized inducer of Heme Oxygenase (HO)-1 by interacting with Keap1 via a Michael addition reaction involving its α, β-unsaturated carbonyl group. This leads to the nuclear translocation of Nrf2 and activation of the HO-1 E2 enhancer, effectively suppressing LPS-induced NO release.
Dehydrocurdione
Copy Product Info🥰Excellent
Catalog No. TN6867
Dehydrocurdione is a sesquiterpene derived from zedoary with potent anti-inflammatory and antioxidant properties. It functions as a specialized inducer of Heme Oxygenase (HO)-1 by interacting with Keap1 via a Michael addition reaction involving its α, β-unsaturated carbonyl group. This leads to the nuclear translocation of Nrf2 and activation of the HO-1 E2 enhancer, effectively suppressing LPS-induced NO release.
Cas No. 38230-32-9
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $143 | - | In Stock | |
| 5 mg | $350 | - | In Stock | |
| 10 mg | $518 | - | In Stock | |
| 25 mg | $843 | - | In Stock | |
| 50 mg | $1,160 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.86%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Dehydrocurdione is a sesquiterpene derived from zedoary with potent anti-inflammatory and antioxidant properties. It functions as a specialized inducer of Heme Oxygenase (HO)-1 by interacting with Keap1 via a Michael addition reaction involving its α, β-unsaturated carbonyl group. This leads to the nuclear translocation of Nrf2 and activation of the HO-1 E2 enhancer, effectively suppressing LPS-induced NO release. |
| In vitro | In vitro, Dehydrocurdione induces HO-1 expression in RAW 264.7 cells. Treatment with 100 μM Dehydrocurdione significantly increases HO-1 mRNA levels within 3 hours, with protein levels peaking at 6 hours. Western Blot analysis confirms promoted nuclear translocation of Nrf2 [1]. |
| In vivo | In vivo, Dehydrocurdione (120 mg/kg, p.o.) significantly reduces chronic adjuvant arthritis in Wistar rats. In Sprague-Dawley rats, a dose of 200 mg/kg (p.o.) inhibits carrageenan-induced paw edema [2]. |
| Molecular Weight | 234.34 |
| Formula | C15H22O2 |
| Cas No. | 38230-32-9 |
| Smiles | O=C(C/C1=C(C)/C)[C@@H](C)CC/C=C(C)\CC1=O |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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