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Nanatinostat

Name: Nanatinostat
Brand: TargetMol
SKU: T16270
Price: 182 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16270Cas No. 1256448-47-1

Alias CHR-3996, CHR3996

Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.

Nanatinostat

🥰Excellent

Purity: 99.03%

Catalog No. T16270Alias CHR-3996, CHR3996Cas No. 1256448-47-1

Pack Size	Price	Availability
1 mg	$182	In Stock
5 mg	$452	In Stock
10 mg	$785	In Stock
25 mg	$1,450	In Stock
50 mg	$1,890	In Stock
100 mg	$2,830	In Stock
1 mL x 10 mM (in DMSO)	$452	In Stock

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Purity:99.03%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.
Targets&IC50	HDAC6:2100 nM, HDAC5:200 nM, HDAC1:3 nM, HDAC:8 nM, HDAC2:4 nM, HDAC3:7 nM
In vitro	Methods: Nanatinostat (CHR-3996) (30 mg/kg, oral) was used to treat NOD/SCID mice that were inoculated subcutaneously with 2×10^6 H929 myeloma cells on the right flank. Caliper measurements of the longest vertical tumor diameter (length) and width were performed every other day. Results: Nanatinostat slowed tumor growth in tumor-bearing mice. [2]
In vivo	Methods: H929, KMS11, LP-1, MM1-S, and RPMI-8828 cells were treated with Nanatinostat (CHR-3996) (0.0001-100 μM), and cell proliferation was detected by WST-1. Results: The LC50 values of various cell lines treated with Nanatinostat ranged from 30.3-97.6 nM. [1]
Alias	CHR-3996, CHR3996

Chemical Properties

Molecular Weight	394.4
Formula	C₂₀H₁₉FN₆O₂
Cas No.	1256448-47-1
Smiles	N(CC1=NC2=C(C=C1)C=C(F)C=C2)[C@H]3[C@]4([C@@]3(CN(C4)C=5N=CC(C(NO)=O)=CN5)[H])[H]
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (101.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5355 mL	12.6775 mL	25.3550 mL	126.7748 mL
5 mM	0.5071 mL	2.5355 mL	5.0710 mL	25.3550 mL
10 mM	0.2535 mL	1.2677 mL	2.5355 mL	12.6775 mL
20 mM	0.1268 mL	0.6339 mL	1.2677 mL	6.3387 mL
50 mM	0.0507 mL	0.2535 mL	0.5071 mL	2.5355 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc