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Nanatinostat

Name: Nanatinostat
Brand: TargetMol
SKU: T16270
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16270Cas No. 1256448-47-1

Alias CHR-3996, CHR3996

Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.

Nanatinostat

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Purity: 99.03%

Catalog No. T16270Alias CHR-3996, CHR3996Cas No. 1256448-47-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$529	In Stock	In Stock
25 mg	$993	In Stock	In Stock
50 mg	$1,570	In Stock	In Stock
100 mg	$2,360	-	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.03%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.
Targets&IC50	HDAC6:2100 nM, HDAC:8 nM, HDAC3:7 nM, HDAC5:200 nM, HDAC2:4 nM, HDAC1:3 nM
In vitro	Methods: Nanatinostat (CHR-3996) (30 mg/kg, oral) was used to treat NOD/SCID mice that were inoculated subcutaneously with 2×10^6 H929 myeloma cells on the right flank. Caliper measurements of the longest vertical tumor diameter (length) and width were performed every other day. Results: Nanatinostat slowed tumor growth in tumor-bearing mice. [2]
In vivo	Methods: H929, KMS11, LP-1, MM1-S, and RPMI-8828 cells were treated with Nanatinostat (CHR-3996) (0.0001-100 μM), and cell proliferation was detected by WST-1. Results: The LC50 values of various cell lines treated with Nanatinostat ranged from 30.3-97.6 nM. [1]
Synonyms	CHR-3996, CHR3996

Chemical Properties

Molecular Weight	394.4
Formula	C₂₀H₁₉FN₆O₂
Cas No.	1256448-47-1
Smiles	N(CC1=NC2=C(C=C1)C=C(F)C=C2)[C@H]3[C@]4([C@@]3(CN(C4)C=5N=CC(C(NO)=O)=CN5)[H])[H]
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (101.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5355 mL	12.6775 mL	25.3550 mL	126.7748 mL
5 mM	0.5071 mL	2.5355 mL	5.0710 mL	25.3550 mL
10 mM	0.2535 mL	1.2677 mL	2.5355 mL	12.6775 mL
20 mM	0.1268 mL	0.6339 mL	1.2677 mL	6.3387 mL
50 mM	0.0507 mL	0.2535 mL	0.5071 mL	2.5355 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc