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Nanatinostat

🥰Excellent
Catalog No. T16270Cas No. 1256448-47-1
Alias CHR-3996, CHR3996

Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.

Nanatinostat

Nanatinostat

🥰Excellent
Purity: 99.03%
Catalog No. T16270Alias CHR-3996, CHR3996Cas No. 1256448-47-1
Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.
Pack SizePriceAvailabilityQuantity
1 mg$182In Stock
5 mg$452In Stock
10 mg$785In Stock
25 mg$1,450In Stock
50 mg$1,890In Stock
100 mg$2,830In Stock
1 mL x 10 mM (in DMSO)$452In Stock
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Purity:99.03%
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Product Introduction

Bioactivity
Description
Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.
Targets&IC50
HDAC6:2100 nM, HDAC5:200 nM, HDAC1:3 nM, HDAC:8 nM, HDAC2:4 nM, HDAC3:7 nM
In vitro
Methods: Nanatinostat (CHR-3996) (30 mg/kg, oral) was used to treat NOD/SCID mice that were inoculated subcutaneously with 2×10^6 H929 myeloma cells on the right flank. Caliper measurements of the longest vertical tumor diameter (length) and width were performed every other day. Results: Nanatinostat slowed tumor growth in tumor-bearing mice. [2]
In vivo
Methods: H929, KMS11, LP-1, MM1-S, and RPMI-8828 cells were treated with Nanatinostat (CHR-3996) (0.0001-100 μM), and cell proliferation was detected by WST-1.
Results: The LC50 values ​​of various cell lines treated with Nanatinostat ranged from 30.3-97.6 nM. [1]
AliasCHR-3996, CHR3996
Chemical Properties
Molecular Weight394.4
FormulaC20H19FN6O2
Cas No.1256448-47-1
SmilesN(CC1=NC2=C(C=C1)C=C(F)C=C2)[C@H]3[C@]4([C@@]3(CN(C4)C=5N=CC(C(NO)=O)=CN5)[H])[H]
Relative Density.1.51 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (101.42 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5355 mL12.6775 mL25.3550 mL126.7748 mL
5 mM0.5071 mL2.5355 mL5.0710 mL25.3550 mL
10 mM0.2535 mL1.2677 mL2.5355 mL12.6775 mL
20 mM0.1268 mL0.6339 mL1.2677 mL6.3387 mL
50 mM0.0507 mL0.2535 mL0.5071 mL2.5355 mL
100 mM0.0254 mL0.1268 mL0.2535 mL1.2677 mL

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