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Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $182 | In Stock | |
5 mg | $452 | In Stock | |
10 mg | $785 | In Stock | |
25 mg | $1,450 | In Stock | |
50 mg | $1,890 | In Stock | |
100 mg | $2,830 | In Stock | |
1 mL x 10 mM (in DMSO) | $452 | In Stock |
Description | Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer. |
Targets&IC50 | HDAC6:2100 nM, HDAC5:200 nM, HDAC1:3 nM, HDAC:8 nM, HDAC2:4 nM, HDAC3:7 nM |
In vitro | Methods: Nanatinostat (CHR-3996) (30 mg/kg, oral) was used to treat NOD/SCID mice that were inoculated subcutaneously with 2×10^6 H929 myeloma cells on the right flank. Caliper measurements of the longest vertical tumor diameter (length) and width were performed every other day. Results: Nanatinostat slowed tumor growth in tumor-bearing mice. [2] |
In vivo | Methods: H929, KMS11, LP-1, MM1-S, and RPMI-8828 cells were treated with Nanatinostat (CHR-3996) (0.0001-100 μM), and cell proliferation was detected by WST-1. Results: The LC50 values of various cell lines treated with Nanatinostat ranged from 30.3-97.6 nM. [1] |
Alias | CHR-3996, CHR3996 |
Molecular Weight | 394.4 |
Formula | C20H19FN6O2 |
Cas No. | 1256448-47-1 |
Smiles | N(CC1=NC2=C(C=C1)C=C(F)C=C2)[C@H]3[C@]4([C@@]3(CN(C4)C=5N=CC(C(NO)=O)=CN5)[H])[H] |
Relative Density. | 1.51 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (101.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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