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UZH2
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Catalog No. T40357Cas No. 2756566-45-5
Alias UZH2
UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.
UZH2
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Purity: 99.89%
Catalog No. T40357Alias UZH2Cas No. 2756566-45-5
UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $123 | In Stock | In Stock | |
| 5 mg | $313 | In Stock | In Stock | |
| 10 mg | $496 | In Stock | In Stock | |
| 25 mg | $778 | In Stock | In Stock | |
| 50 mg | $987 | In Stock | In Stock | |
| 100 mg | $1,360 | - | In Stock | |
| 500 mg | $2,730 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
UZH2 AI Summary
UZH2 is a promising inhibitor of METTL3 activity, characterized by an IC50 value of 5.0 nM in reducing N6-methyladenosine levels. It boasts excellent solubility at 54000.0 nM in PBS (pH 7.4) and displays a moderate efflux ratio in human Caco-2 cells. When tested for metabolic stability, it has a half-life of 0.4 hours in rat liver microsomes. The compound demonstrates good binding affinity to human METTL3/METTL14, with a Delta Tm of 4.7°C, and effectively thermally stabilizes METTL3 in cells, showing EC50 values of 2000.0 nM in HEK293T cells and 850.0 nM in MOLM-13 cells. It also reduces the m6A/A ratio in poly-adenylated RNA fractions with EC50 values of 700.0 nM in MOLM-13 cells and 2500.0 nM in PC-3 cells. Despite these attributes, its growth inhibition effect is moderate, with GI50 values of 12000.0 nM for MOLM-13 cells and 70000.0 nM for PC-3 cells. Additionally, UZH2 exhibits good permeability across Caco-2 cell monolayers, with a Papp value of 12.0 x 10^-6 cm/s..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM. |
| Synonyms | UZH2 |
| Molecular Weight | 513.63 |
| Formula | C27H37F2N7O |
| Cas No. | 2756566-45-5 |
| Smiles | CNc1cc(ncn1)N1CCC2(CC1)CN(CC(=O)N2)c1cc(F)c(CN2CCC(C)(C)CC2)cc1F |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: < 5.14 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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