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TGFBR2 Protein, Mouse, Recombinant (His)

Catalog No. TMPJ-00335
Synonyms: TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-β type II receptor, TβR-II, TbetaR-II, TGF-β receptor type II, Transforming growth factor-β receptor type II, TGF-β receptor type-2, Tgfbr2, TGF-beta receptor type-2, TGF-beta receptor type II

TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.

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TGFBR2 Protein, Mouse, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg In stock $ 58.00
20 μg 5 days $ 85.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 1680.39ng/ml in the presence of 1ng/ml of recombinant human TGF-beta 1. (Regularly tested)

Description TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
Species Mouse
Expression System HEK293 Cells
Tag C-6xHis
Accession Number Q62312-2
Synonyms TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-β type II receptor, TβR-II, TbetaR-II, TGF-β receptor type II, Transforming growth factor-β receptor type II, TGF-β receptor type-2, Tgfbr2, TGF-beta receptor type-2, TGF-beta receptor type II
Amino Acid Ile24-Asp159
Construction Ile24-Asp159
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 25-38 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinity cell surface receptors: TGF-β receptor type I (TGF-β-RI), TGF-β receptor type II (TGF-β-RII), and TGF-ββ receptor type III (TGF-β-RIII). TGF-β RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-β) receptor subfamily. TGF-β RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

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Keywords

TGFBR2 Protein, Mouse, Recombinant (His) TGFR-2 TGF-b type II receptor TGF-beta type II receptor Transforming growth factor-beta receptor type II TGF-β type II receptor Transforming growth factor-b receptor type II TβR-II TGFR2 TbetaR-II TGF-β receptor type II Transforming growth factor-β receptor type II TGF-β receptor type-2 Tgfbr2 TGFR 2 TGF-beta receptor type-2 TGF-b receptor type-2 TGF-beta receptor type II TGF-b receptor type II recombinant recombinant-proteins proteins protein

 

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