Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EP2 receptor antagonist-2 (CID891729) is a compound that not only serves as an antagonist to the EP2 receptor, blocking its activation by PGE2, but also reduces lactate dehydrogenase (LDH) release triggered by N-methyl-D-aspartate (NMDA).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 347.00 | |
50 mg | In stock | $ 563.00 | |
100 mg | In stock | $ 786.00 | |
500 mg | In stock | $ 1,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 137.00 |
Description | EP2 receptor antagonist-2 (CID891729) is a compound that not only serves as an antagonist to the EP2 receptor, blocking its activation by PGE2, but also reduces lactate dehydrogenase (LDH) release triggered by N-methyl-D-aspartate (NMDA). |
In vivo |
SB 209670 (3 mg kg-1, i.v. bolus + 100 micrograms kg-1, i.v. infusion commencing 15 min prior to LPS ; rats) significantly augmented the hypotension as well as the vascular hyporeactivity to NA caused by endotoxaemia.[5] SB 209670 (3 mg kg-1, i.v. bolus given 15 min prior to LPS ; LPS-rats) resulted in a reduction in 6 h-survival from 71% (control) to 30% and 13%, respectively.[5] SB 209670 (3 mg kg-1, i.v. bolus 15 min prior to LPS ; rats) significantly augmented the serum levels of creatinine, bilirubin, GPT and GOT caused by endotoxin.[5] SB 209670 (3 mg kg-1, i.v. bolus ; rats) significantly augmented the metabolic acidosis caused by LPS.[5] |
Molecular Weight | 309.29 |
Formula | C15H14F3N3O |
CAS No. | 615273-95-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (363.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
EP2 receptor antagonist-2 615273-95-5 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor inhibitor inhibit