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(20802)
Research Areas Research AreasCancer
Cancer comprises a heterogeneous group of diseases characterized by uncontrolled cellular proliferation, leading to the formation of malignant tumors with the capacity to invade surrounding tissues and metastasize to distant organs. In contrast, benign tumors lack metastatic potential. More than 100 distinct cancer types have been identified in humans, with lung, colorectal, breast and gastric cancers among the most prevalent worldwide. Cancer remains one of a leading cause of morbidity and mortality globally. Continued research is essential to elucidate molecular pathogenesis, identify predictive biomarkers, develop targeted and immunotherapeutic strategies, and improve early detection and precision medicine approaches.
Daraxonrasib
RMC-6236, RMC6236, RAS-IN-2
T746982765081-21-6
Daraxonrasib (RMC-6236) is an orally effective and novel triple complex RAS (ON) MULTI inhibitor, which is a potent non covalent inhibitor of multiple RAS variants in GTP binding state. RMC-6236 has anti-tumor activity and can be used in research related to RAS driven tumors. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.
- $52
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RMC-9805
Zoldonrasib, KRAS G12D inhibitor 18, KRAS G12D IN 18
T782122922732-54-3
RMC-9805 (Zoldonrasib) is a mutant-selective covalent KRAS G12D inhibitor with oral activity and significant antitumor activity, inducing tumor cell apoptosis in preclinical models of various KRAS-mutant cancers.
- $129
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MitoSOX Red
T753421003197-00-9In house
MitoSOX Red is a fluorescent dye serving as a mitochondria-targeted fluorescent probe for superoxide, with cell membrane permeability and specificity. Upon oxidation, MitoSOX Red subsequently binds to nucleic acids within mitochondria/nuclei, producing intense red fluorescence, and is employed for detecting mitochondrial superoxide in live cells.
- $44
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Trastuzumab
Cited
T9912180288-69-1
Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer.
- $157
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CitedLinsitinib Cited
OSI-906
T6017867160-71-2
Linsitinib (OSI-906) belongs to small molecule inhibitors and is a dual IGF-1/IR inhibitor (IC50 = 35 and 75 nM, respectively) with selectivity, cell permeability, and oral activity. This compound is used in antitumor research and can effectively inhibit cell proliferation and induce apoptosis.
- $33
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CitedRSL3 Cited
RSL3 1S, 1S,3R-RSL3
T36461219810-16-8
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.
- $33
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CitedBI-2493
T720612937344-16-4In house
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
- $538
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Bafilomycin A1 Cited
Baf A1
T674088899-55-2
Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.
- $195
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CitedTrastuzumab deruxtecan Cited
VRN-101099, T-DXd, DS-8201a, DS 8201
T366461826843-81-5
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate functioning as a HER2-targeted topoisomerase I inhibitor, with targeting capability and antitumor activity, employed in research on HER2-positive breast cancer and gastric cancer.
- $521
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CitedCetuximab Cited
Cetuximab (anti-EGFR), C225
T9905205923-56-4
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis.
- $197
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CitedCHIR-99021 Cited
Laduviglusib, CT99021, CHIR-99021
T2310252917-06-9
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in mouse and human embryonic stem cells.
- $36
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CitedY-27632 dihydrochloride Cited
Y-27632 2HCl
T1725129830-38-2
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
- $31
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CitedErastin Cited
T1765571203-78-6
Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations.
- $41
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CitedPembrolizumab Cited
Pembrolizumab(anti-PD-1)
T99081374853-91-4
Pembrolizumab (MK-3475) is a highly selective humanized monoclonal antibody that antagonizes PD-1. It can block the PD-1 protein on T cells and prevent their interaction with PD-L1 on cancer cells.
- $218
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CitedFerrostatin-1 Cited
Ferrostatin-1 (Fer-1), Ferrostatin 1
T6500347174-05-4
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and antifungal activities.
- $59
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CitedBevacizumab Cited
T9904216974-75-3
Bevacizumab, a humanized monoclonal antibody, specifically and with high affinity binds to all isoforms of VEGF-A.
- $129
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CitedZ-VAD-FMK Cited
Z-VAD(OH)-FMK, Caspase Inhibitor VI
T7020161401-82-7
Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not inhibit UCHL1 activity, even at concentrations up to 440 μM.
- $121
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CitedForskolin Cited
FSK, Colforsin, Coleonol
T293966575-29-9
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.
- $36
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CitedVerteporfin Cited
CL 318952, BPD-MA
T3112129497-78-5
Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.
- $34
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CitedTirzepatide
LY-3298176
TP11112023788-19-2
Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) (EC50=0.042 nM) and glucagon-like peptide-1 (GLP-1) (EC50=0.086 nM) receptors, and it has neuroprotective activity. It can improve blood pressure and lower low-density lipoprotein (LDL) cholesterol and triglycerides, and can be used to study diabetes and obesity.
- $266
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MG-132 Cited
Z-LLL-al, Z-Leu-Leu-Leu-CHO, MG132
T2154133407-82-6
MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.
- $40
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CitedValspodar
PSC 833
T17216121584-18-7
Valspodar (PSC 833) is a small-molecule inhibitor and a P-glycoprotein (P-gp) inhibitor with high selectivity and chemosensitizing properties. This compound can effectively reverse P-gp-mediated multidrug resistance (MDR) and is used in experimental research on drug-resistant tumors such as advanced epithelial ovarian cancer.
- $212
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20-HETE Cited
20-hydroxy Arachidonic Acid
T1402179551-86-3In house
20-HETE belongs to endogenous metabolites (natural products) and is a protein kinase C (PKC) pathway activator that promotes ACSL4 ubiquitination and degradation through upregulation of FBXO10, possessing regulatory properties on cell proliferation and migration. This compound is used in research related to prostate tumors and cardiac hypertrophy.
- $498
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