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AMPC
🥰Excellent
Catalog No. T39792Cas No. 2254434-33-6
AMPC is a TFF3 inhibitor with antitumor activity and inhibits tumor growth in vivo. AMPC inhibits cell proliferation and survival in TFF3-positive CMS4 colorectal cancer cells and can be used to study colorectal cancer.
AMPC
🥰Excellent
Purity: 98.97%
Catalog No. T39792Cas No. 2254434-33-6
AMPC is a TFF3 inhibitor with antitumor activity and inhibits tumor growth in vivo. AMPC inhibits cell proliferation and survival in TFF3-positive CMS4 colorectal cancer cells and can be used to study colorectal cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | - | In Stock | |
| 5 mg | $123 | - | In Stock | |
| 10 mg | $198 | - | In Stock | |
| 25 mg | $439 | - | In Stock | |
| 50 mg | $646 | - | In Stock | |
| 100 mg | $918 | - | In Stock | |
| 500 mg | $1,860 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | AMPC is a TFF3 inhibitor with antitumor activity and inhibits tumor growth in vivo. AMPC inhibits cell proliferation and survival in TFF3-positive CMS4 colorectal cancer cells and can be used to study colorectal cancer. |
| Targets&IC50 | SW620 cells:2.63 μM, SW480 cells:69.69 μM, Caco-2 cells:4.65 μM |
| In vitro | The IC50 values of AMPC in CMS4 CRC cells were determined. We observed that SW620 cells with high TFF3 expression were slightly more sensitive to AMPC than Caco2 cells with low TFF3 expression. SW620 IC50=2.63 μM; Caco2 IC50=4.65 μM; SW480 IC50=69.69 μM. [1] |
| In vivo | SW620 cells were subcutaneously injected into nude mice. The mice were randomly divided into two groups (n = 8) and intraperitoneally injected daily with AMPC at a dose of 40 mg/kg body weight or equivalent amount of vehicle for two weeks. The average tumour weight of the AMPC -treated group was significantly less than that of the vehicle-treated group. AMPC treatment resulted in larger areas of tumour necrosis and increased area of cells with apoptotic features. AMPC treatment significantly reduced tumour and serum TFF3 levels. [1] |
| Molecular Weight | 425.41 |
| Formula | C25H16FN3O3 |
| Cas No. | 2254434-33-6 |
| Smiles | N#CC1=C(OC=2C=3C=CC=CC3OC(=O)C2C1C4=CC=C(C=C4)C=5C=NC(F)=C(C5)C)N |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (235.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.75 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: buy AMPC | purchase AMPC | AMPC cost | order AMPC | AMPC chemical structure | AMPC in vivo | AMPC in vitro | AMPC formula | AMPC molecular weight
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