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AMPC
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Catalog No. T39792Cas No. 2254434-33-6
AMPC is a TFF3 inhibitor with antitumor activity and inhibits tumor growth in vivo. AMPC inhibits cell proliferation and survival in TFF3-positive CMS4 colorectal cancer cells and can be used to study colorectal cancer.
AMPC
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Purity: 98.97%
Catalog No. T39792Cas No. 2254434-33-6
AMPC is a TFF3 inhibitor with antitumor activity and inhibits tumor growth in vivo. AMPC inhibits cell proliferation and survival in TFF3-positive CMS4 colorectal cancer cells and can be used to study colorectal cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | - | In Stock | |
| 5 mg | $123 | - | In Stock | |
| 10 mg | $198 | - | In Stock | |
| 25 mg | $439 | - | In Stock | |
| 50 mg | $646 | - | In Stock | |
| 100 mg | $918 | - | In Stock | |
| 500 mg | $1,860 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.97%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AMPC is a TFF3 inhibitor with antitumor activity and inhibits tumor growth in vivo. AMPC inhibits cell proliferation and survival in TFF3-positive CMS4 colorectal cancer cells and can be used to study colorectal cancer. |
| Targets&IC50 | SW480 cells:69.69 μM, SW620 cells:2.63 μM, Caco-2 cells:4.65 μM |
| In vitro | The IC50 values of AMPC in CMS4 CRC cells were determined. We observed that SW620 cells with high TFF3 expression were slightly more sensitive to AMPC than Caco2 cells with low TFF3 expression. SW620 IC50=2.63 μM; Caco2 IC50=4.65 μM; SW480 IC50=69.69 μM. [1] |
| In vivo | SW620 cells were subcutaneously injected into nude mice. The mice were randomly divided into two groups (n = 8) and intraperitoneally injected daily with AMPC at a dose of 40 mg/kg body weight or equivalent amount of vehicle for two weeks. The average tumour weight of the AMPC -treated group was significantly less than that of the vehicle-treated group. AMPC treatment resulted in larger areas of tumour necrosis and increased area of cells with apoptotic features. AMPC treatment significantly reduced tumour and serum TFF3 levels. [1] |
| Molecular Weight | 425.41 |
| Formula | C25H16FN3O3 |
| Cas No. | 2254434-33-6 |
| Smiles | N#CC1=C(OC=2C=3C=CC=CC3OC(=O)C2C1C4=CC=C(C=C4)C=5C=NC(F)=C(C5)C)N |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (235.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.75 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: buy AMPC | purchase AMPC | AMPC cost | order AMPC | AMPC chemical structure | AMPC in vivo | AMPC in vitro | AMPC formula | AMPC molecular weight
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