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(S,R,S)-AHPC-PEG4-NH2 hydrochloride

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Catalog No. T15190Cas No. 2064292-52-8
Alias VHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7

(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.

(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Other Forms of (S,R,S)-AHPC-PEG4-NH2 hydrochloride:
(S,R,S)-AHPC-PEG4-NH2T15190L2010159-57-4
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(S,R,S)-AHPC-PEG4-NH2 hydrochloride

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Catalog No. T15190Alias VHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7Cas No. 2064292-52-8
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$315 days5 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.
In vitro
Extracted from the patent US20170008904A1, '(S,R,S)-AHPC-PEG4-NH2 hydrochloride' serves as a reagent for synthesizing 'compound A1895' as demonstrated in example 3[1].
SynonymsVHL Ligand-Linker Conjugates 4 hydrochloride, VH032-PEG4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 7
Chemical Properties
Molecular Weight700.29
FormulaC32H50ClN5O8S
Cas No.2064292-52-8
SmilesC([C@@H](NC(COCCOCCOCCOCCN)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1.Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 50 mg/mL (71.4 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.4280 mL7.1399 mL14.2798 mL71.3990 mL
5 mM0.2856 mL1.4280 mL2.8560 mL14.2798 mL
10 mM0.1428 mL0.7140 mL1.4280 mL7.1399 mL
20 mM0.0714 mL0.3570 mL0.7140 mL3.5699 mL
50 mM0.0286 mL0.1428 mL0.2856 mL1.4280 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VHL Ligand-Linker Conjugates 4 HydrochlorideVHLVH032-PEG4-NH2 HydrochlorideAHPC-PEG4-NH2 Hydrochloride(S,R,S)-AHPC-PEG-4-NH2 hydrochloride(S,R,S)AHPCPEG4NH2 hydrochloride(S,R,S) AHPC PEG4 NH2 hydrochloride
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