Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry |
Description | Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis. |
In vitro | Thailanstatin D (0-50 nM; 4 hours) significantly reduces AR-V7 and other AR splice variants (AR-Vs)[1] protein levels, while also dose-dependently suppressing mRNA levels of both AR-V7 and AR-FL. This was observed in VCaP, 22RV1, and LN95 cell lines subjected to a Cell Viability Assay[1] with a concentration range of 0-50 nM over a 4-hour incubation period. |
In vivo | Thailanstatin D, administered at a dosage of 300 μg/kg through ALZET osmotic pumps daily for four days, significantly inhibited tumor growth in an animal model of NOD-SCID mice bearing 22RV1 xenografts. |
Molecular Weight | 519.635 |
Formula | C28H41NO8 |
CAS No. | 1609105-89-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Thailanstatin D 1609105-89-6 inhibitor inhibit