FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.

RC32 induced FKBP12 degradation in Hep3B and HuH7 with DC50 values at 0.9 and 0.4 nM. [2]
RC32 demonstrated the ability for FKBP12 degradation resulted in 50% protein degradation (DC50) of ~0.3 nM after only 12 h of treatment in Jurkat cells. [3]

The FKBP12 protein in most of the organs of treated mice, except for the brain, was undetectable after only 1 day of treatment with RC32 (intraperitoneal (i.p.) injection, 30 mg/kg, twice a day). A significant degradation of FKBP12 also occurred in the eyes. RC32 had no effect on FKBP12 degradation in brain tissues. [3]
When Bama pigs (20 kg) were given RC32 (8 mg/kg, twice a day) for 2 days, the FKBP12 protein was efficiently degraded in most of the organs examined. [3]
After 3 days of administration (8 mg/kg, i.p., twice a day), FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of monkeys was efficiently degraded by RC32. [3]