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tri-GalNAc-COOH

Name: tri-GalNAc-COOH
Brand: TargetMol
SKU: T39370
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39370Cas No. 1953146-81-0

Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) and is commonly used in lysosomal targeting chimera (LYTAC) investigations.

tri-GalNAc-COOH

🥰Excellent

Purity: 99.13%

Catalog No. T39370Cas No. 1953146-81-0

Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) and is commonly used in lysosomal targeting chimera (LYTAC) investigations.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$255	In Stock	In Stock
5 mg	$639	In Stock	In Stock
10 mg	$891	In Stock	In Stock
25 mg	$1,370	In Stock	In Stock
50 mg	$1,830	In Stock	In Stock
100 mg	$2,490	In Stock	In Stock
500 mg	$4,980	-	In Stock
1 mL x 10 mM (in DMSO)	$1,220	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.13%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) and is commonly used in lysosomal targeting chimera (LYTAC) investigations.
In vitro	Tri-GalNAc-COOH, a biotin-free ASGPR ligand, cannot effectively transport NA-650 to HepG2, Huh7, or A549 cells [1].

Chemical Properties

Molecular Weight	1735.91
Formula	C₇₅H₁₃₄N₁₀O₃₅
Cas No.	1953146-81-0
Smiles	CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O)(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O)NC(=O)CCOCCOCCOCCOCCOCCC(O)=O
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (129.6 mM), Sonication is recommended.

H2O: 20 mg/mL (11.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (2.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5761 mL	2.8803 mL	5.7607 mL	28.8033 mL
5 mM	0.1152 mL	0.5761 mL	1.1521 mL	5.7607 mL
10 mM	0.0576 mL	0.2880 mL	0.5761 mL	2.8803 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0288 mL	0.1440 mL	0.2880 mL	1.4402 mL
50 mM	0.0115 mL	0.0576 mL	0.1152 mL	0.5761 mL
100 mM	0.0058 mL	0.0288 mL	0.0576 mL	0.2880 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc