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tri-GalNAc-COOH

Name: tri-GalNAc-COOH
Brand: TargetMol
SKU: T39370
Price: 243 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39370Cas No. 1953146-81-0

Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) and is commonly used in lysosomal targeting chimera (LYTAC) investigations.

tri-GalNAc-COOH

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Purity: 99.88%

Catalog No. T39370Cas No. 1953146-81-0

Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) and is commonly used in lysosomal targeting chimera (LYTAC) investigations.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$243	In Stock	In Stock
5 mg	$608	In Stock	In Stock
10 mg	$853	In Stock	In Stock
25 mg	$1,360	In Stock	In Stock
50 mg	$1,830	In Stock	In Stock
100 mg	$2,480	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$1,220	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) and is commonly used in lysosomal targeting chimera (LYTAC) investigations.
In vitro	Tri-GalNAc-COOH, a biotin-free ASGPR ligand, cannot effectively transport NA-650 to HepG2, Huh7, or A549 cells [1].

Chemical Properties

Molecular Weight	1735.91
Formula	C₇₅H₁₃₄N₁₀O₃₅
Cas No.	1953146-81-0
Smiles	CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O)(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O)NC(=O)CCOCCOCCOCCOCCOCCC(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (129.62 mM), Sonication is recommended.

H2O: 20 mg/mL (11.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (2.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5761 mL	2.8803 mL	5.7607 mL	28.8033 mL
5 mM	0.1152 mL	0.5761 mL	1.1521 mL	5.7607 mL
10 mM	0.0576 mL	0.2880 mL	0.5761 mL	2.8803 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0288 mL	0.1440 mL	0.2880 mL	1.4402 mL
50 mM	0.0115 mL	0.0576 mL	0.1152 mL	0.5761 mL
100 mM	0.0058 mL	0.0288 mL	0.0576 mL	0.2880 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc