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Biotin-C4-amide-C5-NH2

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Catalog No. T38999Cas No. 151294-96-1
Alias Biotin-C4-amide-C5-NH2

Biotin-C4-amide-C5-NH2 is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs).

Biotin-C4-amide-C5-NH2

Biotin-C4-amide-C5-NH2

🥰Excellent
Catalog No. T38999Alias Biotin-C4-amide-C5-NH2Cas No. 151294-96-1
Biotin-C4-amide-C5-NH2 is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs).
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Product Introduction

Bioactivity
Description
Biotin-C4-amide-C5-NH2 is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs consist of an antibody conjugated to a cytotoxin via a linker [1].
SynonymsBiotin-C4-amide-C5-NH2
Chemical Properties
Molecular Weight314.45
FormulaC14H26N4O2S
Cas No.151294-96-1
SmilesNCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Relative Density.1.148 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Biotin-C-4-amide-C5-NH2BiotinC4amideC5NH2Biotin C4 amide C5 NH2ADCLinkerADC Linker
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