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TNG-462

Name: TNG-462
Brand: TargetMol
SKU: T79873
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79873Cas No. 2760483-96-1

Alias TNG462

TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies).

TNG-462

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Purity: 98.7%

Catalog No. T79873Alias TNG462Cas No. 2760483-96-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$158	In Stock	In Stock
5 mg	$283	In Stock	In Stock
10 mg	$425	In Stock	In Stock
25 mg	$639	In Stock	In Stock
50 mg	$959	In Stock	In Stock
100 mg	$1,450	-	In Stock
200 mg	$1,950	-	In Stock
1 mL x 10 mM (in DMSO)	$326	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.7%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies).
In vitro	Methods: Tumor cells (NSCLC, PDAC, bladder, hematological malignancies) deficient in MTAP were treated with TNG-462 (0-1 μM) and cell viability was measured. Results: TNG-462 selectively inhibited cell viability with an IC50 value of less than 1 μM. [2]
In vivo	Methods: TNG-462 (40 mg twice a day; 100 mg/kg twice a day, orally, for 21 days) was used to treat a xenograft mouse model derived from a MTAP-deficient cell line and observe tumor growth in vivo. Results: TNG-462 inhibited tumor growth in mice and showed anti-tumor activity. [2]
Synonyms	TNG462

Chemical Properties

Molecular Weight	520.69
Formula	C₂₈H₃₆N₆O₂S
Cas No.	2760483-96-1
Smiles	C(C(NC=1C=C(CC)C(N)=NC1)=O)(=O)N2[C@H](CC[C@H](C)C2)C=3C=C4C(=CC3)SC(=N4)C5CCN(C)CC5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (153.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9205 mL	9.6026 mL	19.2053 mL	96.0264 mL
5 mM	0.3841 mL	1.9205 mL	3.8411 mL	19.2053 mL
10 mM	0.1921 mL	0.9603 mL	1.9205 mL	9.6026 mL
20 mM	0.0960 mL	0.4801 mL	0.9603 mL	4.8013 mL
50 mM	0.0384 mL	0.1921 mL	0.3841 mL	1.9205 mL
100 mM	0.0192 mL	0.0960 mL	0.1921 mL	0.9603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc