Pomalidomide-6-O-CH3

Name: Pomalidomide-6-O-CH3
Brand: TargetMol
SKU: T39033
Rating: 4.5 (1 reviews)

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Catalog No. T39033Cas No. 1547163-08-5

Alias Pomalidomide-6-O-CH3

Pomalidomide-6-O-CH3 is a Pomalidomide-derived ligand for cereblon (CRBN), which serves as a linkage agent to recruit the CRBN protein. This ligand, when connected to a protein via a linker, enables the formation of PROTAC.

Pomalidomide-6-O-CH3

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Catalog No. T39033Alias Pomalidomide-6-O-CH3Cas No. 1547163-08-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Pomalidomide-6-O-CH3 is a Pomalidomide-derived ligand for cereblon (CRBN), which serves as a linkage agent to recruit the CRBN protein. This ligand, when connected to a protein via a linker, enables the formation of PROTAC.
In vitro	PROTACs consist of two distinct ligands joined by a linker: one targets an E3 ubiquitin ligase and the other targets a specific protein. By utilizing the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].
Synonyms	Pomalidomide-6-O-CH3

Chemical Properties

Molecular Weight	303.274
Formula	C₁₄H₁₃N₃O₅
Cas No.	1547163-08-5
Smiles	COc1cc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c(N)c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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