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Rhodblock 6

Name: Rhodblock 6
Brand: TargetMol
SKU: T26078
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26078Cas No. 886625-06-5

Alias Rhodblock-6, Rhodblock6

Rhodblock 6 is a Rho kinase (ROCK) inhibitor that specifically inhibits Rho kinase activity and the localization of phosphorylated MRLC (Myosin Regulatory Light Chain).

Rhodblock 6

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Purity: 99.87%

Catalog No. T26078Alias Rhodblock-6, Rhodblock6Cas No. 886625-06-5

Rhodblock 6 is a Rho kinase (ROCK) inhibitor that specifically inhibits Rho kinase activity and the localization of phosphorylated MRLC (Myosin Regulatory Light Chain).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$153	In Stock	In Stock
50 mg	$226	In Stock	In Stock
100 mg	$322	In Stock	In Stock
200 mg	$453	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:Purple

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Rhodblock 6 is a Rho kinase (ROCK) inhibitor that specifically inhibits Rho kinase activity and the localization of phosphorylated MRLC (Myosin Regulatory Light Chain).
In vitro	Rhodblock 6 (1-30 μM) strongly inhibits ROCK activity in a dose-dependent manner and, at 100 μM for 20 hours, can cause the rupture of stress fibers in human HeLa cells.[1]
Synonyms	Rhodblock-6, Rhodblock6

Chemical Properties

Molecular Weight	215.25
Formula	C₁₂H₁₃N₃O
Cas No.	886625-06-5
Smiles	N(C(=O)C1CCC1)C=2C=C3C(=CC2)NN=C3
Relative Density.	1.386 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (255.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6458 mL	23.2288 mL	46.4576 mL	232.2880 mL
5 mM	0.9292 mL	4.6458 mL	9.2915 mL	46.4576 mL
10 mM	0.4646 mL	2.3229 mL	4.6458 mL	23.2288 mL
20 mM	0.2323 mL	1.1614 mL	2.3229 mL	11.6144 mL
50 mM	0.0929 mL	0.4646 mL	0.9292 mL	4.6458 mL
100 mM	0.0465 mL	0.2323 mL	0.4646 mL	2.3229 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc