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3-Methoxysalicylaldehyde

Name: 3-Methoxysalicylaldehyde
Brand: TargetMol
SKU: TN6748
Rating: 4.5 (1 reviews)

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Catalog No. TN6748Cas No. 148-53-8

3-Methoxysalicylaldehyde is a natural product.

3-Methoxysalicylaldehyde

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Purity: 99.59%

Catalog No. TN6748Cas No. 148-53-8

3-Methoxysalicylaldehyde is a natural product.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

3-Methoxysalicylaldehyde AI Summary

3-Methoxysalicylaldehyde exhibits variable partition coefficients (logP) across different solvents, with higher values in chloroform (2.3) and benzene (1.87), suggesting a preference for non-polar environments. It shows bioactivity in various assays, including inhibition of IRE-1α enzyme (IC50 values of 2370.0 nM and 5750.0 nM) and synthetic amyloid beta-42 fibrillation, where it demonstrates 89.0% inhibition and an IC50 value of 6150.0 nM for amyloid beta-42 oligomerization. Additionally, 3-Methoxysalicylaldehyde protects against venom-induced mortality and hemorrhage in Swiss albino mice and displays antiviral activity against SARS-CoV-2 by inhibiting the virus-induced cytotoxicity of VERO-6 cells at a concentration of 10 µM, although its IC50 value exceeds 20000.0 nM. This compound's bioactivities, influenced by its partitioning behavior, suggest potential as a therapeutic agent for conditions such as amyloid beta aggregation, IRE-1α related cellular processes, venom exposure, and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

3-Methoxysalicylaldehyde is a natural product.

Chemical Properties

Molecular Weight	152.15
Formula	C₈H₈O₃
Cas No.	148-53-8
Smiles	COC1=CC=CC(C=O)=C1O
Relative Density.	1.2143 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (394.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5725 mL	32.8623 mL	65.7246 mL	328.6231 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL	65.7246 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL	32.8623 mL
20 mM	0.3286 mL	1.6431 mL	3.2862 mL	16.4312 mL
50 mM	0.1314 mL	0.6572 mL	1.3145 mL	6.5725 mL
100 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2862 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc