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LYG-202
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Catalog No. T36488Cas No. 1175077-25-4
Alias LYG202, LYG 202
LYG-202 is a novel flavonoid with piperazine substitution and antitumor effects in vivo and in vitro.LYG-202 induced apoptosis in MCF-7, MDA-MB-231, and MDA-MB-435 cells, and increased intracellular ROS production.
LYG-202
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Purity: 97.27%
Catalog No. T36488Alias LYG202, LYG 202Cas No. 1175077-25-4
LYG-202 is a novel flavonoid with piperazine substitution and antitumor effects in vivo and in vitro.LYG-202 induced apoptosis in MCF-7, MDA-MB-231, and MDA-MB-435 cells, and increased intracellular ROS production.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $37 | In Stock | In Stock | |
| 5 mg | $97 | In Stock | In Stock | |
| 10 mg | $163 | In Stock | In Stock | |
| 25 mg | $372 | In Stock | In Stock | |
| 50 mg | $549 | In Stock | In Stock | |
| 100 mg | $783 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.27%
Appearance:Solid
Color:Yellow
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Product Introduction
LYG-202 AI Summary
LYG-202 shows cytotoxic activity against various human cell lines, including HepG2, A549, and BCG823 cells, as demonstrated by a reduction in cell viability after 48 hours using the MTT assay. The compound exhibits differing IC50 values, with the most significant cytotoxic effect observed in BCG823 cells (IC50 = 5300.0 nM), followed by HepG2 cells (IC50 = 1120.0 nM and 1122.02 nM), and A549 cells (IC50 = 1500.0 nM)..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LYG-202 is a novel flavonoid with piperazine substitution and antitumor effects in vivo and in vitro.LYG-202 induced apoptosis in MCF-7, MDA-MB-231, and MDA-MB-435 cells, and increased intracellular ROS production. |
| Synonyms | LYG202, LYG 202 |
| Molecular Weight | 438.52 |
| Formula | C25H30N2O5 |
| Cas No. | 1175077-25-4 |
| Smiles | COc1c(OCCCCN2CCN(C)CC2)cc(O)c2c1oc(cc2=O)-c1ccccc1 |
| Relative Density. | 1.218 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol: 2.5 mg/mL (5.7 mM), Sonication is recommended. DMF: 14 mg/mL (31.93 mM), Sonication is recommended. DMSO: 4.39 mg/mL (10.01 mM), Sonication is recommended.  DMF:PBS (pH7.2) (1:40): 0.12 mg/mL (0.27 mM), Sonication is recommended. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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