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Aeruginosin 865
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Catalog No. T39077Cas No. 1611990-01-2
Aeruginosin 865, a compound extracted from the terrestrial cyanobacterium Nostoc sp. Luke ová 30/93, represents the inaugural aeruginosin-type peptide to incorporate a fatty acid and a carbohydrate moiety. It functions by inhibiting the translocation of NF-kB to the nucleus, thereby exerting an anti-inflammatory effect.
Aeruginosin 865
😃Good
Catalog No. T39077Cas No. 1611990-01-2
Aeruginosin 865, a compound extracted from the terrestrial cyanobacterium Nostoc sp. Luke ová 30/93, represents the inaugural aeruginosin-type peptide to incorporate a fatty acid and a carbohydrate moiety. It functions by inhibiting the translocation of NF-kB to the nucleus, thereby exerting an anti-inflammatory effect.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aeruginosin 865, a compound extracted from the terrestrial cyanobacterium Nostoc sp. Luke ová 30/93, represents the inaugural aeruginosin-type peptide to incorporate a fatty acid and a carbohydrate moiety. It functions by inhibiting the translocation of NF-kB to the nucleus, thereby exerting an anti-inflammatory effect. |
| In vitro | Aeruginosin 865, when pre-treated at concentrations ranging from 0.1 to 100 μg/mL, significantly inhibits IL-8 (EC 50 = 3.5 μg/mL) and ICAM-1 (EC 50 = 50.0 μg/mL) in a concentration-dependent manner in hTNF-α-stimulated HLMVECs, without compromising cell viability in HeLa and HepG2 cells even at much higher concentrations[1]. Furthermore, at concentrations of 100-200 μM, Aeruginosin 865 exhibits cytotoxicity towards Mouse fibrosarcoma cells, while demonstrating no cytotoxic effects on NIH/3T3 cells[2]. |
| Molecular Weight | 864.991 |
| Formula | C41H64N6O14 |
| Cas No. | 1611990-01-2 |
| Smiles | [H][C@]12C[C@@H](N(C(=O)[C@@H](CC(C)C)NC(=O)[C@H](O)Cc3ccc(O)cc3)[C@@]1([H])C[C@H](O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@@H]1O)C(O)=O)[C@H](C2)OC(=O)CCCCC)C(=O)NCCCCNC(N)=N |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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