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(E)-AG 99

Name: (E)-AG 99
Brand: TargetMol
SKU: T5155
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5155Cas No. 122520-85-8

Alias Tyrphostin 46, AG 99, (E)-Tyrphostin AG 99, (E)-Tyrphostin 46

(E)-AG 99 ((E)-Tyrphostin AG 99) is an EGFR kinase inhibitor with an IC50 of 10 μM in the human epidermoid carcinoma cell line A431.

(E)-AG 99

🥰Excellent

Purity: 99.23%

Catalog No. T5155Alias Tyrphostin 46, AG 99, (E)-Tyrphostin AG 99, (E)-Tyrphostin 46Cas No. 122520-85-8

(E)-AG 99 ((E)-Tyrphostin AG 99) is an EGFR kinase inhibitor with an IC50 of 10 μM in the human epidermoid carcinoma cell line A431.

Pack Size	Price	Availability
10 mg	$37	In Stock
25 mg	$65	In Stock
50 mg	$92	In Stock
100 mg	$129	In Stock
200 mg	$189	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Batch Information

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Purity:99.23%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	(E)-AG 99 ((E)-Tyrphostin AG 99) is an EGFR kinase inhibitor with an IC50 of 10 μM in the human epidermoid carcinoma cell line A431.
Targets&IC50	EGFR kinase:10 µM
Synonyms	Tyrphostin 46, AG 99, (E)-Tyrphostin AG 99, (E)-Tyrphostin 46

Chemical Properties

Molecular Weight	204.18
Formula	C₁₀H₈N₂O₃
Cas No.	122520-85-8
Smiles	NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Relative Density.	1.482g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

Ethanol: 1 mg/mL (4.9 mM), Sonication is recommended.

DMSO: 50 mg/mL (244.88 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8976 mL	24.4882 mL	48.9764 mL	244.8820 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
10 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
20 mM	0.2449 mL	1.2244 mL	2.4488 mL	12.2441 mL
50 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8976 mL
100 mM	0.0490 mL	0.2449 mL	0.4898 mL	2.4488 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc