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Pitavastatin

Catalog No. T7072 CAS 147511-69-1

Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC 50 of 5.8 nM. It also acts as an efficient inducer of hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors. Furthermore, Pitavastatin exhibits a range of therapeutic activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.

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Pitavastatin, CAS 147511-69-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC 50 of 5.8 nM. It also acts as an efficient inducer of hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors. Furthermore, Pitavastatin exhibits a range of therapeutic activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.
In vitro	Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC 50 =0.4-5 μM) or as spheroids (IC50 = 0.6-4 μM) [4]. Pitavastatin (1 μM; 48 hours ) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 and caspase-8 and caspase-9 in Ovcar-8 cells and Ovcar-3 cells [4]. Pitavastatin (1 μM, 48 hours) resulted in PARP cleavage in Ovcar-8 cells [4]. Western Blot Analysis [1] Cell Line: Ovcar-8 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced PARP cleavage.
In vivo	Pitavastatin (59 mg/kg; p.o.; twice daily for 28 days) resulted in significant tumour regression [4]. Animal Model: 4 week old female NCR Nu/Nu female mice (bearing Ovcar-4 tumours) [4] Dosage: 59 mg/kg Administration: p.o.; twice daily for 28 days Result: Caused significant tumour regression.

Molecular Weight	421.46
Formula	C25H24FNO4
CAS No.	147511-69-1

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pitavastatin 147511-69-1 Compound T7072 inhibitor inhibit

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