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Pitavastatin

Name: Pitavastatin
Brand: TargetMol
SKU: T7072
Rating: 4.5 (1 reviews)

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Catalog No. T7072Cas No. 147511-69-1

Alias NK-104, NK104, NK 104

Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM. It also induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors and exhibits therapeutic activities such as anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.

Pitavastatin

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Purity: 97.17%

Catalog No. T7072Alias NK-104, NK104, NK 104Cas No. 147511-69-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	1-2 weeks	1-2 weeks
10 mg	$45	1-2 weeks	1-2 weeks
25 mg	$64	1-2 weeks	1-2 weeks
50 mg	$92	1-2 weeks	1-2 weeks
100 mg	$133	1-2 weeks	1-2 weeks
500 mg	$328	1-2 weeks	1-2 weeks
1 mL x 10 mM (in DMSO)	$37	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.17%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM. It also induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors and exhibits therapeutic activities such as anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.
In vitro	Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those likely representing HGSOC, with IC50 values of 0.4-5 μM in monolayers and 0.6-4 μM in spheroids [4]. At 1 μM for 48 hours, Pitavastatin induces apoptosis in Ovcar-8 and Ovcar-3 cells, increasing the activity of caspases-3, -7, -8, and -9, and results in PARP cleavage in Ovcar-8 cells, as evidenced by Western Blot analysis [1, 4].
In vivo	In 4-week-old female NCR Nu/Nu nude mice bearing Ovcar-4 tumors, Pitavastatin (administered at a dose of 59 mg/kg; orally (p.o.); twice daily for 28 days) is able to significantly induce tumor regression[4].
Synonyms	NK-104, NK104, NK 104

Chemical Properties

Molecular Weight	421.46
Formula	C₂₅H₂₄FNO₄
Cas No.	147511-69-1
Smiles	C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C1=C(C2=C(N=C1C3CC3)C=CC=C2)C4=CC=C(F)C=C4
Relative Density.	1.352g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.13 mg/mL (78.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3727 mL	11.8635 mL	23.7270 mL	118.6352 mL
5 mM	0.4745 mL	2.3727 mL	4.7454 mL	23.7270 mL
10 mM	0.2373 mL	1.1864 mL	2.3727 mL	11.8635 mL
20 mM	0.1186 mL	0.5932 mL	1.1864 mL	5.9318 mL
50 mM	0.0475 mL	0.2373 mL	0.4745 mL	2.3727 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc