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Pitavastatin

Name: Pitavastatin
Brand: TargetMol
SKU: T7072
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7072Cas No. 147511-69-1

Alias NK-104, NK104, NK 104

Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM. It also induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors and exhibits therapeutic activities such as anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.

Pitavastatin

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Purity: 97.17%

Catalog No. T7072Alias NK-104, NK104, NK 104Cas No. 147511-69-1

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$45	In Stock
25 mg	$64	In Stock
50 mg	$92	In Stock
100 mg	$133	In Stock
500 mg	$328	1-2 weeks
1 mL x 10 mM (in DMSO)	$37	In Stock

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Batch Information

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Purity:97.17%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM. It also induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors and exhibits therapeutic activities such as anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.
In vitro	Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those likely representing HGSOC, with IC50 values of 0.4-5 μM in monolayers and 0.6-4 μM in spheroids [4]. At 1 μM for 48 hours, Pitavastatin induces apoptosis in Ovcar-8 and Ovcar-3 cells, increasing the activity of caspases-3, -7, -8, and -9, and results in PARP cleavage in Ovcar-8 cells, as evidenced by Western Blot analysis [1, 4].
In vivo	In 4-week-old female NCR Nu/Nu nude mice bearing Ovcar-4 tumors, Pitavastatin (administered at a dose of 59 mg/kg; orally (p.o.); twice daily for 28 days) is able to significantly induce tumor regression[4].
Synonyms	NK-104, NK104, NK 104

Chemical Properties

Molecular Weight	421.46
Formula	C₂₅H₂₄FNO₄
Cas No.	147511-69-1
Smiles	C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C1=C(C2=C(N=C1C3CC3)C=CC=C2)C4=CC=C(F)C=C4
Relative Density.	1.352g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (94.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3727 mL	11.8635 mL	23.7270 mL	118.6352 mL
5 mM	0.4745 mL	2.3727 mL	4.7454 mL	23.7270 mL
10 mM	0.2373 mL	1.1864 mL	2.3727 mL	11.8635 mL
20 mM	0.1186 mL	0.5932 mL	1.1864 mL	5.9318 mL
50 mM	0.0475 mL	0.2373 mL	0.4745 mL	2.3727 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc