Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulfo-DGN462 sodium undergoes degradation to DGN462 when subjected to culture medium and plasma. DGN462, a highly effective DNA-alkylating agent, exhibits anti-tumor properties that are particularly active against acute myeloid leukemia (AML).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 1,520.00 |
Description | Sulfo-DGN462 sodium undergoes degradation to DGN462 when subjected to culture medium and plasma. DGN462, a highly effective DNA-alkylating agent, exhibits anti-tumor properties that are particularly active against acute myeloid leukemia (AML). |
In vitro | DGN462 serves as a cytotoxic agent in antibody-drug conjugates (ADCs), demonstrating its utility in targeted cancer therapy. It belongs to the class of DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs), indicating its mechanism of action at the molecular level[1]. |
Synonyms | sulfo-DGN462 sodium |
Molecular Weight | 1047.2 |
Formula | C53H61N5NaO12S2 |
CAS No. | 1401203-09-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
sulfo-DGN462 sodium 1401203-09-5 sulfoDGN462 sodium sulfo DGN462 sodium sulfo-DGN-462 sodium inhibitor inhibit