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SR31527

Name: SR31527
Brand: TargetMol
SKU: T28848
Rating: 4.5 (1 reviews)

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Catalog No. T28848Cas No. 311814-78-5

Alias SR31527 chloride, SR-31527, SR 31527

SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation.

SR31527

😃Good

Catalog No. T28848Alias SR31527 chloride, SR-31527, SR 31527Cas No. 311814-78-5

SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation.

Pack Size	Price	Availability
25 mg	$1,350	6-8 weeks
50 mg	$1,760	6-8 weeks
100 mg	$2,720	6-8 weeks
1 mL x 10 mM (in DMSO)	$439	6-8 weeks

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Product Introduction

Bioactivity

Description	SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation.
Targets&IC50	KIFC1:25.4 nM(Kd), KIFC1:6.6 µM
In vitro	SR31527 (50 µ M ; 24h) induced the formation of multiple Spindle apparatus in MDA-MB-231, BT549 and MDA-MB-435s cells.[1] SR31527 (0-100 µ M ; 96 hours, 10-12 days) reduces the cell viability and colony formation of breast cancer cells, and is less cytotoxic to LL47 cells.[1]
Synonyms	SR31527 chloride, SR-31527, SR 31527

Chemical Properties

Molecular Weight	319.81
Formula	C₁₅H₁₄ClN₃OS
Cas No.	311814-78-5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.2 mg/mL (10.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1269 mL	15.6343 mL	31.2686 mL	156.3428 mL
5 mM	0.6254 mL	3.1269 mL	6.2537 mL	31.2686 mL
10 mM	0.3127 mL	1.5634 mL	3.1269 mL	15.6343 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc