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V-9302 hydrochloride

Name: V-9302 hydrochloride
Brand: TargetMol
SKU: T40064
Rating: 4.5 (1 reviews)

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Catalog No. T40064Cas No. 2416138-42-4

Alias V9302 hydrochloride

V-9302 hydrochloride is a competitive transmembrane glutamine flux antagonist that selectively targets the amino acid transporter ASCT2/SLC1A5. V-9302 hydrochloride impedes glutamine uptake mediated by ASCT2 (IC50=9.6 μM), inhibits the mTOR signalling pathway, increases oxidative stress and ROS levels, induces autophagy, and exerts antitumour effects.

V-9302 hydrochloride

🥰Excellent

Purity: 97.31%

Catalog No. T40064Alias V9302 hydrochlorideCas No. 2416138-42-4

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Purity:97.31%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	V-9302 hydrochloride is a competitive transmembrane glutamine flux antagonist that selectively targets the amino acid transporter ASCT2/SLC1A5. V-9302 hydrochloride impedes glutamine uptake mediated by ASCT2 (IC50=9.6 μM), inhibits the mTOR signalling pathway, increases oxidative stress and ROS levels, induces autophagy, and exerts antitumour effects.
In vitro	V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake in Homo sapiens cells in a concentration-dependent manner, with a potency 100 times higher than γ-L-glutamyl-p-nitroaniline [1]. Pharmacological blockade of ASCT2 by V-9302 hydrochloride reduces cancer cell growth and proliferation, increases cell mortality, and intensifies oxidative stress [1].
In vivo	V-9302 hydrochloride (75 mg/kg, once daily for 21 days) administered intraperitoneally to HCT-116 and HT29 parazacco spilurus subsp. spilurus xenograft mouse models effectively prevents tumor growth [1]. V-9302 hydrochloride (30 mg/kg, once daily, 5 days/week) administered intraperitoneally to SNU398 and MHCC97H parazacco spilurus subsp. spilurus xenograft models, when combined with CB-839, induces significant tumor growth inhibition, while monotherapy shows moderate antitumor effects [2]. V-9302 hydrochloride (50 mg/kg, once daily for 5 days) administered intraperitoneally to a mouse triple-negative breast cancer (TNBC) orthotopic tumor model significantly reduces tumor growth [3].
Synonyms	V9302 hydrochloride

Chemical Properties

Molecular Weight	575.14
Formula	C₃₄H₃₉ClN₂O₄
Cas No.	2416138-42-4
Smiles	C(N(CC1=C(OCC2=CC(C)=CC=C2)C=CC=C1)CC[C@@H](C(O)=O)N)C3=C(OCC4=CC(C)=CC=C4)C=CC=C3.Cl
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (69.55 mM)

DMSO: 80 mg/mL (139.1 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7387 mL	8.6935 mL	17.3871 mL	86.9354 mL
5 mM	0.3477 mL	1.7387 mL	3.4774 mL	17.3871 mL
10 mM	0.1739 mL	0.8694 mL	1.7387 mL	8.6935 mL
20 mM	0.0869 mL	0.4347 mL	0.8694 mL	4.3468 mL
50 mM	0.0348 mL	0.1739 mL	0.3477 mL	1.7387 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0174 mL	0.0869 mL	0.1739 mL	0.8694 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc