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Seviteronel racemate

Name: Seviteronel racemate
Brand: TargetMol
SKU: T13313
Rating: 4.5 (1 reviews)

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Catalog No. T13313Cas No. 1375603-36-3

Alias VT-464 (racemate)

Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.

Seviteronel racemate

😃Good

Catalog No. T13313Alias VT-464 (racemate)Cas No. 1375603-36-3

Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$198	6-8 weeks	6-8 weeks
5 mg	$347	6-8 weeks	6-8 weeks
25 mg	$1,140	6-8 weeks	6-8 weeks
50 mg	$1,490	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$382	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase.
Targets&IC50	CYP17 Lyase (human):69 nM
In vivo	The MDA-PCa-133 xenograft, originating from a clinical castration-resistant prostate cancer (CRPC) bone metastasis, exhibits expression of PSA, the full-length androgen receptor (AR), and the AR-V7 isoform subcutaneously. In a study involving castrated male mice bearing the MDA-PCa-133 tumor, subjects were divided into three groups and underwent 25 days of oral treatment with either a vehicle, Seviteronel (VT-464) at 100 mg/kg twice daily, or Abiraterone Acetate (AA) at 100 mg/kg twice daily. Results demonstrated that both Seviteronel (VT-464) and AA significantly reduced tumor volume by more than two-fold relative to the vehicle group (p<0.05). The study highlights that Seviteronel’s (VT-464) selective CYP17 lyase inhibition is comparably effective to AA’s CYP17 inhibition in reducing tumor volume in this model [2].
Synonyms	VT-464 (racemate)

Chemical Properties

Molecular Weight	399.34
Formula	C₁₈H₁₇F₄N₃O₃
Cas No.	1375603-36-3
Relative Density.	1.393 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (125.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.26 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5041 mL	12.5207 mL	25.0413 mL	125.2066 mL
5 mM	0.5008 mL	2.5041 mL	5.0083 mL	25.0413 mL
10 mM	0.2504 mL	1.2521 mL	2.5041 mL	12.5207 mL
20 mM	0.1252 mL	0.6260 mL	1.2521 mL	6.2603 mL
50 mM	0.0501 mL	0.2504 mL	0.5008 mL	2.5041 mL
100 mM	0.0250 mL	0.1252 mL	0.2504 mL	1.2521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc