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AZD0022
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Catalog No. T204084Cas No. 2958627-18-2
Alias AZD 0022
AZD0022 is a selective and orally active KRAS G12D inhibitor that displays exposure-dependent pRSK inhibition in a GP2D xenograft model.
AZD0022
😃Good
Catalog No. T204084Alias AZD 0022Cas No. 2958627-18-2
AZD0022 is a selective and orally active KRAS G12D inhibitor that displays exposure-dependent pRSK inhibition in a GP2D xenograft model.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | 10-14 weeks | |
| 5 mg | Inquiry | 10-14 weeks | |
| 10 mg | Inquiry | 10-14 weeks | |
| 25 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AZD0022 is a selective and orally active KRAS G12D inhibitor that displays exposure-dependent pRSK inhibition in a GP2D xenograft model. |
| In vitro | PKPD modelling of AZD0022 suggested an unbound IC50 of 1.4 nM for pRSK inhibition[1]. |
| In vivo | In nude mice bearing GP2D human tumor xenografts, oral dosing of AZD0022 at 150 mg/kg led to sustained plasma and tumor exposure, with tumor concentrations approximately 18-fold higher than plasma. Seven days of BID dosing at 150 mg/kg resulted in up to 75% inhibition of pRSK, with dose-dependent target modulation observed across 10, 50, and 150 mg/kg[1]. |
| Alias | AZD 0022 |
| Molecular Weight | 614.64 |
| Formula | C34H30F4N6O |
| Cas No. | 2958627-18-2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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